The PharmacoGx package is a popular tool from the Bioconductor project within the field of bioinformatics and computational biology. Whereas the gDR package is a valuable tool that provides the framework for the import, processing, analysism and visualization of high-dimensional drug response data, the PharmacoGx package provides functionality to containerize processed drug response and genomic data to perform pharmacogenomic analyses. The data structure used by PharmacoGx is described as a PharamcoSet class, inherited from CoreGx::CoreSet. Inspired by the SummarizedExperiment class, a new data structure class called the TreatmentResponseExperiment was developed to store drug response data within the PharmacoSet.
In collaboration with the BHKLab, we have developed functionality to convert between the gDR-generated MultiAssayExperiment (MAE) object and the PharmacoSet object (see the ConvertingPharmacoSetToGDR vignette to convert from a PharmacoSet to gDR object).
This workflow assumes that you have already generated a MAE object using the gDR package. We will load in a MAE object generated using the data from the KW. Song et al, 2022 study. This MAE contains two drugs (treatments) and 7 cell lines (samples).
(mae <- qs::qread(
system.file("extdata", "kyung2022mae", "MAE_E2.qs", package = "gDRimport")
)
)
#> A MultiAssayExperiment object of 2 listed
#> experiments with user-defined names and respective classes.
#> Containing an ExperimentList class object of length 2:
#> [1] matrix: SummarizedExperiment with 1 rows and 7 columns
#> [2] single-agent: SummarizedExperiment with 2 rows and 7 columns
#> Functionality:
#> experiments() - obtain the ExperimentList instance
#> colData() - the primary/phenotype DataFrame
#> sampleMap() - the sample coordination DataFrame
#> `$`, `[`, `[[` - extract colData columns, subset, or experiment
#> *Format() - convert into a long or wide DataFrame
#> assays() - convert ExperimentList to a SimpleList of matrices
#> exportClass() - save data to flat filesFirst we will view the experiments and assays within the MultiAssayExperiment object.
gDRutils::MAEpply(mae, assays)
#> $matrix
#> List of length 14
#> names(14): RawTreated Controls Normalized ... CIScore_50 CIScore_80 Metrics
#>
#> $`single-agent`
#> List of length 5
#> names(5): RawTreated Controls Normalized Averaged MetricsWe will now convert the MAE object into a PharmacoSet object. We need to provide a name for the data object, in this example we will use the name of the study.
We can now view the PharmacoSet object.
pset
#> <PharmacoSet>
#> Name: Kyung2022
#> Date Created: Tue Oct 24 17:17:15 2023
#> Number of samples: 7
#> Molecular profiles:
#> A MultiAssayExperiment object of 1 listed
#> experiment with a user-defined name and respective class.
#> Containing an ExperimentList class object of length 1:
#> [1] emptySE: SummarizedExperiment with 0 rows and 7 columns
#> Treatment response:
#> <TreatmentResponseExperiment>
#> dim: 3 7
#> assays(14): RawTreated Controls Normalized Averaged SmoothMatrix BlissExcess
#> HSAExcess all_iso_points isobolograms BlissScore HSAScore CIScore_50
#> CIScore_80 Metrics
#> rownames(3): G02001876_Palbociclib_CDK4|CDK6_168 G02967907_GDC-0077_PI3K-A_168 G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> rowData(10): treatmentid Gnumber DrugName ... DrugName_3 drug_moa_3 Duration
#> colnames(7): CL129757_MCF-7_Breast_MCF-7_unknown_30 CL130218_BT-474_Breast_BT-474_unknown_70 CL130742_T-47D_Breast_T-47D_unknown_60 ... CL131873_HCC1428_Breast_HCC1428_unknown_74 CL131891_EFM-19_Breast_EFM-19_unknown_64 CL131903_BT-483_Breast_BT-483_unknown_130
#> colData(7): sampleid clid CellLineName ... parental_identifier subtype ReferenceDivisionTime
#> metadata(0): noneWe can view information about the drugs and cell lines in the PharmacoSet object using the treatment and sample slots:
head(treatmentInfo(pset))
#> treatmentid
#> 1 G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 2 G02001876_Palbociclib_CDK4|CDK6_168
#> 3 G02967907_GDC-0077_PI3K-A_168
#> Gnumber DrugName drug_moa Gnumber_2 DrugName_2 drug_moa_2 DrugName_3
#> 1 G02967907 GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 2 G02001876 Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 3 G02967907 GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> drug_moa_3 Duration
#> 1 vehicle 168
#> 2 <NA> 168
#> 3 <NA> 168
head(sampleInfo(pset))
#> sampleid
#> CL129757_MCF-7_Breast_MCF-7_unknown_30 CL129757_MCF-7_Breast_MCF-7_unknown_30
#> CL130218_BT-474_Breast_BT-474_unknown_70 CL130218_BT-474_Breast_BT-474_unknown_70
#> CL130742_T-47D_Breast_T-47D_unknown_60 CL130742_T-47D_Breast_T-47D_unknown_60
#> CL131438_CAMA-1_Breast_CAMA-1_unknown_53 CL131438_CAMA-1_Breast_CAMA-1_unknown_53
#> CL131873_HCC1428_Breast_HCC1428_unknown_74 CL131873_HCC1428_Breast_HCC1428_unknown_74
#> CL131891_EFM-19_Breast_EFM-19_unknown_64 CL131891_EFM-19_Breast_EFM-19_unknown_64
#> clid CellLineName Tissue
#> CL129757_MCF-7_Breast_MCF-7_unknown_30 CL129757 MCF-7 Breast
#> CL130218_BT-474_Breast_BT-474_unknown_70 CL130218 BT-474 Breast
#> CL130742_T-47D_Breast_T-47D_unknown_60 CL130742 T-47D Breast
#> CL131438_CAMA-1_Breast_CAMA-1_unknown_53 CL131438 CAMA-1 Breast
#> CL131873_HCC1428_Breast_HCC1428_unknown_74 CL131873 HCC1428 Breast
#> CL131891_EFM-19_Breast_EFM-19_unknown_64 CL131891 EFM-19 Breast
#> parental_identifier subtype
#> CL129757_MCF-7_Breast_MCF-7_unknown_30 MCF-7 unknown
#> CL130218_BT-474_Breast_BT-474_unknown_70 BT-474 unknown
#> CL130742_T-47D_Breast_T-47D_unknown_60 T-47D unknown
#> CL131438_CAMA-1_Breast_CAMA-1_unknown_53 CAMA-1 unknown
#> CL131873_HCC1428_Breast_HCC1428_unknown_74 HCC1428 unknown
#> CL131891_EFM-19_Breast_EFM-19_unknown_64 EFM-19 unknown
#> ReferenceDivisionTime batchid
#> CL129757_MCF-7_Breast_MCF-7_unknown_30 30 1
#> CL130218_BT-474_Breast_BT-474_unknown_70 70 1
#> CL130742_T-47D_Breast_T-47D_unknown_60 60 1
#> CL131438_CAMA-1_Breast_CAMA-1_unknown_53 53 1
#> CL131873_HCC1428_Breast_HCC1428_unknown_74 74 1
#> CL131891_EFM-19_Breast_EFM-19_unknown_64 64 1The TreatmentResponseExperiment is a new class that was developed to store drug response data within the PharmacoSet object. This vignette will cover some basics about this class, however for more information, please refer to the PharmacoSet vignette TreatmentResponseExperiment****.
tre <- treatmentResponse(pset)
head(rownames(tre))
#> [1] "G02001876_Palbociclib_CDK4|CDK6_168"
#> [2] "G02967907_GDC-0077_PI3K-A_168"
#> [3] "G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168"
head(rowData(tre))
#> treatmentid
#> 1: G02001876_Palbociclib_CDK4|CDK6_168
#> 2: G02967907_GDC-0077_PI3K-A_168
#> 3: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> Gnumber DrugName drug_moa Gnumber_2 DrugName_2 drug_moa_2 DrugName_3
#> 1: G02001876 Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 2: G02967907 GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 3: G02967907 GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> drug_moa_3 Duration
#> 1: <NA> 168
#> 2: <NA> 168
#> 3: vehicle 168head(colnames(tre))
#> [1] "CL129757_MCF-7_Breast_MCF-7_unknown_30"
#> [2] "CL130218_BT-474_Breast_BT-474_unknown_70"
#> [3] "CL130742_T-47D_Breast_T-47D_unknown_60"
#> [4] "CL131438_CAMA-1_Breast_CAMA-1_unknown_53"
#> [5] "CL131873_HCC1428_Breast_HCC1428_unknown_74"
#> [6] "CL131891_EFM-19_Breast_EFM-19_unknown_64"
head(colData(tre))
#> sampleid clid CellLineName Tissue
#> 1: CL129757_MCF-7_Breast_MCF-7_unknown_30 CL129757 MCF-7 Breast
#> 2: CL130218_BT-474_Breast_BT-474_unknown_70 CL130218 BT-474 Breast
#> 3: CL130742_T-47D_Breast_T-47D_unknown_60 CL130742 T-47D Breast
#> 4: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 CL131438 CAMA-1 Breast
#> 5: CL131873_HCC1428_Breast_HCC1428_unknown_74 CL131873 HCC1428 Breast
#> 6: CL131891_EFM-19_Breast_EFM-19_unknown_64 CL131891 EFM-19 Breast
#> parental_identifier subtype ReferenceDivisionTime
#> 1: MCF-7 unknown 30
#> 2: BT-474 unknown 70
#> 3: T-47D unknown 60
#> 4: CAMA-1 unknown 53
#> 5: HCC1428 unknown 74
#> 6: EFM-19 unknown 64data.table SubsettingIn addition to regex queries, a TreatmentResponseExperiment object supports arbitrarily complex subset queries using the data.table API. To access this API, you will need to use the . function, which allows you to pass raw R expressions to be evaluated inside the i and j arguments for dataTable[i, j].
For example if we want to subset to rows where the cell line is “CL131891_EFM-19_Breast_EFM-19_unknown_64” and drug is “G02967907_GDC-0077_PI3K-A_168”.
tre[
.(treatmentid=="G02967907_GDC-0077_PI3K-A_168"), # query on row
.(sampleid=="CL131891_EFM-19_Breast_EFM-19_unknown_64") # query on column
]
#> <TreatmentResponseExperiment>
#> dim: 1 1
#> assays(14): RawTreated Controls Normalized Averaged SmoothMatrix BlissExcess
#> HSAExcess all_iso_points isobolograms BlissScore HSAScore CIScore_50
#> CIScore_80 Metrics
#> rownames(1): G02967907_GDC-0077_PI3K-A_168
#> rowData(10): treatmentid Gnumber DrugName ... DrugName_3 drug_moa_3 Duration
#> colnames(1): CL131891_EFM-19_Breast_EFM-19_unknown_64
#> colData(7): sampleid clid CellLineName ... parental_identifier subtype ReferenceDivisionTime
#> metadata(0): noneWe can also invert matches or subset on other columns in rowData or colData:
tre[
.(treatmentid!="G02967907_GDC-0077_PI3K-A_168"), # query on row
.(sampleid!="CL131891_EFM-19_Breast_EFM-19_unknown_64") # query on column
]
#> <TreatmentResponseExperiment>
#> dim: 2 6
#> assays(14): RawTreated Controls Normalized Averaged SmoothMatrix BlissExcess
#> HSAExcess all_iso_points isobolograms BlissScore HSAScore CIScore_50
#> CIScore_80 Metrics
#> rownames(2): G02001876_Palbociclib_CDK4|CDK6_168 G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> rowData(10): treatmentid Gnumber DrugName ... DrugName_3 drug_moa_3 Duration
#> colnames(6): CL129757_MCF-7_Breast_MCF-7_unknown_30 CL130218_BT-474_Breast_BT-474_unknown_70 CL130742_T-47D_Breast_T-47D_unknown_60 CL131438_CAMA-1_Breast_CAMA-1_unknown_53 CL131873_HCC1428_Breast_HCC1428_unknown_74 CL131903_BT-483_Breast_BT-483_unknown_130
#> colData(7): sampleid clid CellLineName ... parental_identifier subtype ReferenceDivisionTime
#> metadata(0): noneThe assays can be viewed through the assays function. Each assay has a column “data_type” which references which SummarizedExperiment from the MAE the data corresponds with.
assays(tre)
#> $RawTreated
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> ---
#> 1620: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 1621: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 1622: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 1623: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 1624: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> ---
#> 1620: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 1621: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 1622: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 1623: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 1624: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> ---
#> 1620: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 1621: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 1622: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 1623: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 1624: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> ---
#> 1620: T-47D 60 Breast CL130742 T-47D
#> 1621: CAMA-1 53 Breast CL131438 CAMA-1
#> 1622: HCC1428 74 Breast CL131873 HCC1428
#> 1623: EFM-19 64 Breast CL131891 EFM-19
#> 1624: BT-483 130 Breast CL131903 BT-483
#> subtype data_type Concentration Concentration_2 Barcode ReadoutValue
#> 1: <NA> single-agent 0.001524158 NA 30190103p 921614
#> 2: <NA> single-agent 0.001524158 NA 30190103p 999312
#> 3: <NA> single-agent 0.001524158 NA 30190103p 1104556
#> 4: <NA> single-agent 0.001524158 NA 30190103p 1122112
#> 5: <NA> single-agent 0.004572471 NA 30190103p 874807
#> ---
#> 1620: unknown matrix 10.000000000 0.1499999 30190103g 67428
#> 1621: unknown matrix 10.000000000 0.1499999 30190103l 104078
#> 1622: unknown matrix 10.000000000 0.1499999 30190103e 896670
#> 1623: unknown matrix 10.000000000 0.1499999 30190103c 41908
#> 1624: unknown matrix 10.000000000 0.1499999 30190103k 366573
#> BackgroundValue Template WellRow WellColumn
#> 1: 483 Template_0077_Palbo_7daytreated.xlsx D 20
#> 2: 483 Template_0077_Palbo_7daytreated.xlsx C 20
#> 3: 483 Template_0077_Palbo_7daytreated.xlsx D 19
#> 4: 483 Template_0077_Palbo_7daytreated.xlsx C 19
#> 5: 483 Template_0077_Palbo_7daytreated.xlsx C 18
#> ---
#> 1620: 599 Template_0077_Palbo_7daytreated.xlsx O 3
#> 1621: 274 Template_0077_Palbo_7daytreated.xlsx P 4
#> 1622: 403 Template_0077_Palbo_7daytreated.xlsx P 4
#> 1623: 521 Template_0077_Palbo_7daytreated.xlsx P 4
#> 1624: 328 Template_0077_Palbo_7daytreated.xlsx O 4
#> record_id masked CorrectedReadout swap_sa i.Gnumber i.DrugName
#> 1: 2832 FALSE 921131 NA G02001876 Palbociclib
#> 2: 2831 FALSE 998829 NA G02001876 Palbociclib
#> 3: 2830 FALSE 1104073 NA G02001876 Palbociclib
#> 4: 2829 FALSE 1121629 NA G02001876 Palbociclib
#> 5: 2835 FALSE 874324 NA G02001876 Palbociclib
#> ---
#> 1620: 3301 FALSE 66829 TRUE G02967907 GDC-0077
#> 1621: 1384 FALSE 103804 TRUE G02967907 GDC-0077
#> 1622: 2344 FALSE 896267 TRUE G02967907 GDC-0077
#> 1623: 1864 FALSE 41387 TRUE G02967907 GDC-0077
#> 1624: 903 FALSE 366245 TRUE G02967907 GDC-0077
#> i.drug_moa i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3
#> 1: CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 2: CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 3: CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 4: CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 5: CDK4|CDK6 <NA> <NA> <NA> <NA>
#> ---
#> 1620: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 1621: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 1622: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 1623: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 1624: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> i.drug_moa_3 i.Duration i.clid i.CellLineName i.Tissue
#> 1: <NA> 168 CL129757 MCF-7 Breast
#> 2: <NA> 168 CL129757 MCF-7 Breast
#> 3: <NA> 168 CL129757 MCF-7 Breast
#> 4: <NA> 168 CL129757 MCF-7 Breast
#> 5: <NA> 168 CL129757 MCF-7 Breast
#> ---
#> 1620: vehicle 168 CL130742 T-47D Breast
#> 1621: vehicle 168 CL131438 CAMA-1 Breast
#> 1622: vehicle 168 CL131873 HCC1428 Breast
#> 1623: vehicle 168 CL131891 EFM-19 Breast
#> 1624: vehicle 168 CL131903 BT-483 Breast
#> i.parental_identifier i.subtype i.ReferenceDivisionTime
#> 1: MCF-7 unknown 30
#> 2: MCF-7 unknown 30
#> 3: MCF-7 unknown 30
#> 4: MCF-7 unknown 30
#> 5: MCF-7 unknown 30
#> ---
#> 1620: T-47D unknown 60
#> 1621: CAMA-1 unknown 53
#> 1622: HCC1428 unknown 74
#> 1623: EFM-19 unknown 64
#> 1624: BT-483 unknown 130
#>
#> $Controls
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> ---
#> 6884: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 6885: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 6886: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 6887: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 6888: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> ---
#> 6884: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 6885: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 6886: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 6887: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 6888: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> ---
#> 6884: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 6885: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 6886: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 6887: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 6888: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> ---
#> 6884: T-47D 60 Breast CL130742 T-47D
#> 6885: CAMA-1 53 Breast CL131438 CAMA-1
#> 6886: HCC1428 74 Breast CL131873 HCC1428
#> 6887: EFM-19 64 Breast CL131891 EFM-19
#> 6888: BT-483 130 Breast CL131903 BT-483
#> subtype data_type control_type CorrectedReadout record_id Barcode
#> 1: <NA> single-agent Day0Readout 97219 2401 20190103p
#> 2: <NA> single-agent Day0Readout 97219 2402 20190103p
#> 3: <NA> single-agent Day0Readout 97219 2403 20190103p
#> 4: <NA> single-agent Day0Readout 97219 2404 20190103p
#> 5: <NA> single-agent Day0Readout 97219 2405 20190103p
#> ---
#> 6884: unknown matrix UntrtReadout 939324 3358 30190103g
#> 6885: unknown matrix UntrtReadout 1394886 1436 30190103l
#> 6886: unknown matrix UntrtReadout 2060266 2393 30190103e
#> 6887: unknown matrix UntrtReadout 868252 1916 30190103c
#> 6888: unknown matrix UntrtReadout 768455 953 30190103k
#> isDay0 i.Gnumber i.DrugName i.drug_moa i.Gnumber_2 i.DrugName_2
#> 1: TRUE G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> 2: TRUE G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> 3: TRUE G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> 4: TRUE G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> 5: TRUE G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> ---
#> 6884: FALSE G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> 6885: FALSE G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> 6886: FALSE G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> 6887: FALSE G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> 6888: FALSE G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid i.CellLineName
#> 1: <NA> <NA> <NA> 168 CL129757 MCF-7
#> 2: <NA> <NA> <NA> 168 CL129757 MCF-7
#> 3: <NA> <NA> <NA> 168 CL129757 MCF-7
#> 4: <NA> <NA> <NA> 168 CL129757 MCF-7
#> 5: <NA> <NA> <NA> 168 CL129757 MCF-7
#> ---
#> 6884: CDK4|CDK6 vehicle vehicle 168 CL130742 T-47D
#> 6885: CDK4|CDK6 vehicle vehicle 168 CL131438 CAMA-1
#> 6886: CDK4|CDK6 vehicle vehicle 168 CL131873 HCC1428
#> 6887: CDK4|CDK6 vehicle vehicle 168 CL131891 EFM-19
#> 6888: CDK4|CDK6 vehicle vehicle 168 CL131903 BT-483
#> i.Tissue i.parental_identifier i.subtype i.ReferenceDivisionTime
#> 1: Breast MCF-7 unknown 30
#> 2: Breast MCF-7 unknown 30
#> 3: Breast MCF-7 unknown 30
#> 4: Breast MCF-7 unknown 30
#> 5: Breast MCF-7 unknown 30
#> ---
#> 6884: Breast T-47D unknown 60
#> 6885: Breast CAMA-1 unknown 53
#> 6886: Breast HCC1428 unknown 74
#> 6887: Breast EFM-19 unknown 64
#> 6888: Breast BT-483 unknown 130
#>
#> $Normalized
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> ---
#> 3244: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 3245: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 3246: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 3247: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 3248: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> ---
#> 3244: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 3245: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 3246: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 3247: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 3248: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> ---
#> 3244: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 3245: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 3246: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 3247: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 3248: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> ---
#> 3244: T-47D 60 Breast CL130742 T-47D
#> 3245: CAMA-1 53 Breast CL131438 CAMA-1
#> 3246: HCC1428 74 Breast CL131873 HCC1428
#> 3247: EFM-19 64 Breast CL131891 EFM-19
#> 3248: BT-483 130 Breast CL131903 BT-483
#> subtype data_type Concentration Concentration_2 masked
#> 1: <NA> single-agent 0.001524158 NA FALSE
#> 2: <NA> single-agent 0.001524158 NA FALSE
#> 3: <NA> single-agent 0.001524158 NA FALSE
#> 4: <NA> single-agent 0.001524158 NA FALSE
#> 5: <NA> single-agent 0.004572471 NA FALSE
#> ---
#> 3244: unknown matrix 0.149999911 10 FALSE
#> 3245: unknown matrix 0.149999911 10 FALSE
#> 3246: unknown matrix 0.149999911 10 FALSE
#> 3247: unknown matrix 0.149999911 10 FALSE
#> 3248: unknown matrix 0.149999911 10 FALSE
#> normalization_type x i.Gnumber i.DrugName i.drug_moa i.Gnumber_2
#> 1: RV 0.8253 G02001876 Palbociclib CDK4|CDK6 <NA>
#> 2: RV 0.8949 G02001876 Palbociclib CDK4|CDK6 <NA>
#> 3: RV 0.9892 G02001876 Palbociclib CDK4|CDK6 <NA>
#> 4: RV 1.0049 G02001876 Palbociclib CDK4|CDK6 <NA>
#> 5: RV 0.7833 G02001876 Palbociclib CDK4|CDK6 <NA>
#> ---
#> 3244: GR -0.1768 G02967907 GDC-0077 PI3K-A G02001876
#> 3245: GR -0.0595 G02967907 GDC-0077 PI3K-A G02001876
#> 3246: GR 0.6040 G02967907 GDC-0077 PI3K-A G02001876
#> 3247: GR -0.3903 G02967907 GDC-0077 PI3K-A G02001876
#> 3248: GR -0.4992 G02967907 GDC-0077 PI3K-A G02001876
#> i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid
#> 1: <NA> <NA> <NA> <NA> 168 CL129757
#> 2: <NA> <NA> <NA> <NA> 168 CL129757
#> 3: <NA> <NA> <NA> <NA> 168 CL129757
#> 4: <NA> <NA> <NA> <NA> 168 CL129757
#> 5: <NA> <NA> <NA> <NA> 168 CL129757
#> ---
#> 3244: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 3245: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 3246: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 3247: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 3248: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: MCF-7 Breast MCF-7 unknown
#> 2: MCF-7 Breast MCF-7 unknown
#> 3: MCF-7 Breast MCF-7 unknown
#> 4: MCF-7 Breast MCF-7 unknown
#> 5: MCF-7 Breast MCF-7 unknown
#> ---
#> 3244: T-47D Breast T-47D unknown
#> 3245: CAMA-1 Breast CAMA-1 unknown
#> 3246: HCC1428 Breast HCC1428 unknown
#> 3247: EFM-19 Breast EFM-19 unknown
#> 3248: BT-483 Breast BT-483 unknown
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 30
#> 3: 30
#> 4: 30
#> 5: 30
#> ---
#> 3244: 60
#> 3245: 53
#> 3246: 74
#> 3247: 64
#> 3248: 130
#>
#> $Averaged
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> ---
#> 682: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 683: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 684: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 685: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 686: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> sampleid DrugName DrugName_2 DrugName_3
#> 1: <NA> <NA> <NA> <NA>
#> 2: <NA> <NA> <NA> <NA>
#> 3: <NA> <NA> <NA> <NA>
#> 4: <NA> <NA> <NA> <NA>
#> 5: <NA> <NA> <NA> <NA>
#> ---
#> 682: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib vehicle
#> 683: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib vehicle
#> 684: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib vehicle
#> 685: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib vehicle
#> 686: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib vehicle
#> Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3 CellLineName
#> 1: NA <NA> <NA> <NA> <NA> <NA> <NA>
#> 2: NA <NA> <NA> <NA> <NA> <NA> <NA>
#> 3: NA <NA> <NA> <NA> <NA> <NA> <NA>
#> 4: NA <NA> <NA> <NA> <NA> <NA> <NA>
#> 5: NA <NA> <NA> <NA> <NA> <NA> <NA>
#> ---
#> 682: 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle T-47D
#> 683: 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle CAMA-1
#> 684: 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle HCC1428
#> 685: 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle EFM-19
#> 686: 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle BT-483
#> ReferenceDivisionTime Tissue clid parental_identifier subtype
#> 1: NA <NA> <NA> <NA> <NA>
#> 2: NA <NA> <NA> <NA> <NA>
#> 3: NA <NA> <NA> <NA> <NA>
#> 4: NA <NA> <NA> <NA> <NA>
#> 5: NA <NA> <NA> <NA> <NA>
#> ---
#> 682: 60 Breast CL130742 T-47D unknown
#> 683: 53 Breast CL131438 CAMA-1 unknown
#> 684: 74 Breast CL131873 HCC1428 unknown
#> 685: 64 Breast CL131891 EFM-19 unknown
#> 686: 130 Breast CL131903 BT-483 unknown
#> data_type normalization_type Concentration Concentration_2 x
#> 1: single-agent RV 0.001524158 NA 0.928575
#> 2: single-agent GR 0.001524158 NA 0.952225
#> 3: single-agent RV 0.004572471 NA 0.885050
#> 4: single-agent GR 0.004572471 NA 0.923000
#> 5: single-agent RV 0.013717406 NA 0.843800
#> ---
#> 682: matrix GR 10.000000000 0.1 -0.110525
#> 683: matrix GR 10.000000000 0.1 -0.007325
#> 684: matrix GR 10.000000000 0.1 0.129400
#> 685: matrix GR 10.000000000 0.1 -0.359625
#> 686: matrix GR 10.000000000 0.1 -0.591250
#> x_std i.Gnumber i.DrugName i.drug_moa i.Gnumber_2 i.DrugName_2
#> 1: 0.084262739 G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> 2: 0.056755815 G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> 3: 0.070911330 G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> 4: 0.049979996 G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> 5: 0.055852007 G02001876 Palbociclib CDK4|CDK6 <NA> <NA>
#> ---
#> 682: 0.055605298 G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> 683: 0.049715683 G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> 684: 0.075998026 G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> 685: 0.008228963 G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> 686: 0.041410828 G02967907 GDC-0077 PI3K-A G02001876 Palbociclib
#> i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid i.CellLineName
#> 1: <NA> <NA> <NA> 168 CL129757 MCF-7
#> 2: <NA> <NA> <NA> 168 CL129757 MCF-7
#> 3: <NA> <NA> <NA> 168 CL129757 MCF-7
#> 4: <NA> <NA> <NA> 168 CL129757 MCF-7
#> 5: <NA> <NA> <NA> 168 CL129757 MCF-7
#> ---
#> 682: CDK4|CDK6 vehicle vehicle 168 CL130742 T-47D
#> 683: CDK4|CDK6 vehicle vehicle 168 CL131438 CAMA-1
#> 684: CDK4|CDK6 vehicle vehicle 168 CL131873 HCC1428
#> 685: CDK4|CDK6 vehicle vehicle 168 CL131891 EFM-19
#> 686: CDK4|CDK6 vehicle vehicle 168 CL131903 BT-483
#> i.Tissue i.parental_identifier i.subtype i.ReferenceDivisionTime
#> 1: Breast MCF-7 unknown 30
#> 2: Breast MCF-7 unknown 30
#> 3: Breast MCF-7 unknown 30
#> 4: Breast MCF-7 unknown 30
#> 5: Breast MCF-7 unknown 30
#> ---
#> 682: Breast T-47D unknown 60
#> 683: Breast CAMA-1 unknown 53
#> 684: Breast HCC1428 unknown 74
#> 685: Breast EFM-19 unknown 64
#> 686: Breast BT-483 unknown 130
#>
#> $SmoothMatrix
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: <NA>
#> 16: <NA>
#> 17: <NA>
#> 18: <NA>
#> 19: <NA>
#> 20: <NA>
#> 21: <NA>
#> 22: <NA>
#> 23: <NA>
#> 24: <NA>
#> 25: <NA>
#> 26: <NA>
#> 27: <NA>
#> 28: <NA>
#> 29: <NA>
#> 30: <NA>
#> 31: <NA>
#> 32: <NA>
#> 33: <NA>
#> 34: <NA>
#> 35: <NA>
#> 36: <NA>
#> 37: <NA>
#> 38: <NA>
#> 39: <NA>
#> 40: <NA>
#> 41: <NA>
#> 42: <NA>
#> 43: <NA>
#> 44: <NA>
#> 45: <NA>
#> 46: <NA>
#> 47: <NA>
#> 48: <NA>
#> 49: <NA>
#> 50: <NA>
#> 51: <NA>
#> 52: <NA>
#> 53: <NA>
#> 54: <NA>
#> 55: <NA>
#> 56: <NA>
#> 57: G02001876_Palbociclib_CDK4|CDK6_168
#> 58: G02001876_Palbociclib_CDK4|CDK6_168
#> 59: G02001876_Palbociclib_CDK4|CDK6_168
#> 60: G02001876_Palbociclib_CDK4|CDK6_168
#> 61: G02967907_GDC-0077_PI3K-A_168
#> 62: G02967907_GDC-0077_PI3K-A_168
#> 63: G02967907_GDC-0077_PI3K-A_168
#> 64: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 65: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 66: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 67: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 68: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 69: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 70: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: <NA> <NA> <NA>
#> 16: <NA> <NA> <NA>
#> 17: <NA> <NA> <NA>
#> 18: <NA> <NA> <NA>
#> 19: <NA> <NA> <NA>
#> 20: <NA> <NA> <NA>
#> 21: <NA> <NA> <NA>
#> 22: <NA> <NA> <NA>
#> 23: <NA> <NA> <NA>
#> 24: <NA> <NA> <NA>
#> 25: <NA> <NA> <NA>
#> 26: <NA> <NA> <NA>
#> 27: <NA> <NA> <NA>
#> 28: <NA> <NA> <NA>
#> 29: <NA> <NA> <NA>
#> 30: <NA> <NA> <NA>
#> 31: <NA> <NA> <NA>
#> 32: <NA> <NA> <NA>
#> 33: <NA> <NA> <NA>
#> 34: <NA> <NA> <NA>
#> 35: <NA> <NA> <NA>
#> 36: <NA> <NA> <NA>
#> 37: <NA> <NA> <NA>
#> 38: <NA> <NA> <NA>
#> 39: <NA> <NA> <NA>
#> 40: <NA> <NA> <NA>
#> 41: <NA> <NA> <NA>
#> 42: <NA> <NA> <NA>
#> 43: <NA> <NA> <NA>
#> 44: <NA> <NA> <NA>
#> 45: <NA> <NA> <NA>
#> 46: <NA> <NA> <NA>
#> 47: <NA> <NA> <NA>
#> 48: <NA> <NA> <NA>
#> 49: <NA> <NA> <NA>
#> 50: <NA> <NA> <NA>
#> 51: <NA> <NA> <NA>
#> 52: <NA> <NA> <NA>
#> 53: <NA> <NA> <NA>
#> 54: <NA> <NA> <NA>
#> 55: <NA> <NA> <NA>
#> 56: <NA> <NA> <NA>
#> 57: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 58: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 59: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 60: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 61: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 62: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 63: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 64: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 65: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 66: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 67: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 68: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 69: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 70: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 16: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 17: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 18: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 19: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 20: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 21: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 22: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 23: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 24: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 25: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 26: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 27: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 28: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 29: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 30: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 31: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 32: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 33: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 34: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 35: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 36: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 37: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 38: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 39: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 40: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 41: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 42: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 43: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 44: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 45: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 46: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 47: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 48: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 49: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 50: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 51: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 52: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 53: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 54: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 55: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 56: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 57: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 58: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 59: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 60: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 61: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 62: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 63: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 64: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 65: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 66: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 67: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 68: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 69: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 70: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: <NA> NA <NA> <NA> <NA>
#> 16: <NA> NA <NA> <NA> <NA>
#> 17: <NA> NA <NA> <NA> <NA>
#> 18: <NA> NA <NA> <NA> <NA>
#> 19: <NA> NA <NA> <NA> <NA>
#> 20: <NA> NA <NA> <NA> <NA>
#> 21: <NA> NA <NA> <NA> <NA>
#> 22: <NA> NA <NA> <NA> <NA>
#> 23: <NA> NA <NA> <NA> <NA>
#> 24: <NA> NA <NA> <NA> <NA>
#> 25: <NA> NA <NA> <NA> <NA>
#> 26: <NA> NA <NA> <NA> <NA>
#> 27: <NA> NA <NA> <NA> <NA>
#> 28: <NA> NA <NA> <NA> <NA>
#> 29: <NA> NA <NA> <NA> <NA>
#> 30: <NA> NA <NA> <NA> <NA>
#> 31: <NA> NA <NA> <NA> <NA>
#> 32: <NA> NA <NA> <NA> <NA>
#> 33: <NA> NA <NA> <NA> <NA>
#> 34: <NA> NA <NA> <NA> <NA>
#> 35: <NA> NA <NA> <NA> <NA>
#> 36: <NA> NA <NA> <NA> <NA>
#> 37: <NA> NA <NA> <NA> <NA>
#> 38: <NA> NA <NA> <NA> <NA>
#> 39: <NA> NA <NA> <NA> <NA>
#> 40: <NA> NA <NA> <NA> <NA>
#> 41: <NA> NA <NA> <NA> <NA>
#> 42: <NA> NA <NA> <NA> <NA>
#> 43: <NA> NA <NA> <NA> <NA>
#> 44: <NA> NA <NA> <NA> <NA>
#> 45: <NA> NA <NA> <NA> <NA>
#> 46: <NA> NA <NA> <NA> <NA>
#> 47: <NA> NA <NA> <NA> <NA>
#> 48: <NA> NA <NA> <NA> <NA>
#> 49: <NA> NA <NA> <NA> <NA>
#> 50: <NA> NA <NA> <NA> <NA>
#> 51: <NA> NA <NA> <NA> <NA>
#> 52: <NA> NA <NA> <NA> <NA>
#> 53: <NA> NA <NA> <NA> <NA>
#> 54: <NA> NA <NA> <NA> <NA>
#> 55: <NA> NA <NA> <NA> <NA>
#> 56: <NA> NA <NA> <NA> <NA>
#> 57: MCF-7 30 Breast CL129757 MCF-7
#> 58: T-47D 60 Breast CL130742 T-47D
#> 59: HCC1428 74 Breast CL131873 HCC1428
#> 60: BT-483 130 Breast CL131903 BT-483
#> 61: BT-474 70 Breast CL130218 BT-474
#> 62: CAMA-1 53 Breast CL131438 CAMA-1
#> 63: EFM-19 64 Breast CL131891 EFM-19
#> 64: MCF-7 30 Breast CL129757 MCF-7
#> 65: BT-474 70 Breast CL130218 BT-474
#> 66: T-47D 60 Breast CL130742 T-47D
#> 67: CAMA-1 53 Breast CL131438 CAMA-1
#> 68: HCC1428 74 Breast CL131873 HCC1428
#> 69: EFM-19 64 Breast CL131891 EFM-19
#> 70: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type Concentration Concentration_2 x
#> 1: <NA> single-agent NA NA NA
#> 2: <NA> single-agent NA NA NA
#> 3: <NA> single-agent NA NA NA
#> 4: <NA> single-agent NA NA NA
#> 5: <NA> single-agent NA NA NA
#> 6: <NA> single-agent NA NA NA
#> 7: <NA> single-agent NA NA NA
#> 8: <NA> matrix 0.0000000 0.0 1.00000000
#> 9: <NA> matrix 0.0000000 0.0 1.00000000
#> 10: <NA> matrix 0.0000000 0.1 0.38010047
#> 11: <NA> matrix 0.0000000 0.1 0.45569178
#> 12: <NA> matrix 0.1499999 0.0 0.40407827
#> 13: <NA> matrix 0.1499999 0.0 0.46578576
#> 14: <NA> matrix 0.1499999 0.1 -0.02843019
#> 15: <NA> matrix 0.0000000 0.0 1.00000000
#> 16: <NA> matrix 0.0000000 0.0 1.00000000
#> 17: <NA> matrix 0.0000000 0.1 0.34948266
#> 18: <NA> matrix 0.0000000 0.1 0.44916308
#> 19: <NA> matrix 0.1499999 0.0 0.47985839
#> 20: <NA> matrix 0.1499999 0.0 0.80112921
#> 21: <NA> matrix 0.1499999 0.1 -0.02772195
#> 22: <NA> matrix 0.0000000 0.0 1.00000000
#> 23: <NA> matrix 0.0000000 0.0 1.00000000
#> 24: <NA> matrix 0.0000000 0.1 0.16796828
#> 25: <NA> matrix 0.0000000 0.1 0.27730555
#> 26: <NA> matrix 0.1499999 0.0 0.49141491
#> 27: <NA> matrix 0.1499999 0.0 1.10000000
#> 28: <NA> matrix 0.1499999 0.1 -0.12416295
#> 29: <NA> matrix 0.0000000 0.0 1.00000000
#> 30: <NA> matrix 0.0000000 0.0 1.00000000
#> 31: <NA> matrix 0.0000000 0.1 0.72271678
#> 32: <NA> matrix 0.0000000 0.1 0.74697751
#> 33: <NA> matrix 0.1499999 0.0 0.14076971
#> 34: <NA> matrix 0.1499999 0.0 0.16876993
#> 35: <NA> matrix 0.1499999 0.1 0.14152901
#> 36: <NA> matrix 0.0000000 0.0 1.00000000
#> 37: <NA> matrix 0.0000000 0.0 1.00000000
#> 38: <NA> matrix 0.0000000 0.1 0.83746705
#> 39: <NA> matrix 0.0000000 0.1 0.86008545
#> 40: <NA> matrix 0.1499999 0.0 NaN
#> 41: <NA> matrix 0.1499999 0.0 NaN
#> 42: <NA> matrix 0.1499999 0.1 0.50551316
#> 43: <NA> matrix 0.0000000 0.0 1.00000000
#> 44: <NA> matrix 0.0000000 0.0 1.00000000
#> 45: <NA> matrix 0.0000000 0.1 0.02616164
#> 46: <NA> matrix 0.0000000 0.1 0.24766044
#> 47: <NA> matrix 0.1499999 0.0 NaN
#> 48: <NA> matrix 0.1499999 0.0 0.40931425
#> 49: <NA> matrix 0.1499999 0.1 -0.28828549
#> 50: <NA> matrix 0.0000000 0.0 1.00000000
#> 51: <NA> matrix 0.0000000 0.0 1.00000000
#> 52: <NA> matrix 0.0000000 0.1 0.37362542
#> 53: <NA> matrix 0.0000000 0.1 0.83398862
#> 54: <NA> matrix 0.1499999 0.0 0.60064678
#> 55: <NA> matrix 0.1499999 0.0 0.73429319
#> 56: <NA> matrix 0.1499999 0.1 -0.21863342
#> 57: unknown single-agent NA NA NA
#> 58: unknown single-agent NA NA NA
#> 59: unknown single-agent NA NA NA
#> 60: unknown single-agent NA NA NA
#> 61: unknown single-agent NA NA NA
#> 62: unknown single-agent NA NA NA
#> 63: unknown single-agent NA NA NA
#> 64: unknown matrix 0.1499999 0.1 0.10479989
#> 65: unknown matrix 0.1499999 0.1 0.20736749
#> 66: unknown matrix 0.1499999 0.1 0.10382647
#> 67: unknown matrix 0.1499999 0.1 0.16906092
#> 68: unknown matrix 0.1499999 0.1 0.56725342
#> 69: unknown matrix 0.1499999 0.1 0.06890920
#> 70: unknown matrix 0.1499999 0.1 0.59762790
#> subtype data_type Concentration Concentration_2 x
#> normalization_type i.Gnumber i.DrugName i.drug_moa i.Gnumber_2
#> 1: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 2: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 3: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 4: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 5: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 6: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 7: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 8: GR G02967907 GDC-0077 PI3K-A G02001876
#> 9: RV G02967907 GDC-0077 PI3K-A G02001876
#> 10: RV G02967907 GDC-0077 PI3K-A G02001876
#> 11: GR G02967907 GDC-0077 PI3K-A G02001876
#> 12: RV G02967907 GDC-0077 PI3K-A G02001876
#> 13: GR G02967907 GDC-0077 PI3K-A G02001876
#> 14: GR G02967907 GDC-0077 PI3K-A G02001876
#> 15: GR G02967907 GDC-0077 PI3K-A G02001876
#> 16: RV G02967907 GDC-0077 PI3K-A G02001876
#> 17: GR G02967907 GDC-0077 PI3K-A G02001876
#> 18: RV G02967907 GDC-0077 PI3K-A G02001876
#> 19: GR G02967907 GDC-0077 PI3K-A G02001876
#> 20: RV G02967907 GDC-0077 PI3K-A G02001876
#> 21: GR G02967907 GDC-0077 PI3K-A G02001876
#> 22: GR G02967907 GDC-0077 PI3K-A G02001876
#> 23: RV G02967907 GDC-0077 PI3K-A G02001876
#> 24: GR G02967907 GDC-0077 PI3K-A G02001876
#> 25: RV G02967907 GDC-0077 PI3K-A G02001876
#> 26: RV G02967907 GDC-0077 PI3K-A G02001876
#> 27: GR G02967907 GDC-0077 PI3K-A G02001876
#> 28: GR G02967907 GDC-0077 PI3K-A G02001876
#> 29: GR G02967907 GDC-0077 PI3K-A G02001876
#> 30: RV G02967907 GDC-0077 PI3K-A G02001876
#> 31: RV G02967907 GDC-0077 PI3K-A G02001876
#> 32: GR G02967907 GDC-0077 PI3K-A G02001876
#> 33: GR G02967907 GDC-0077 PI3K-A G02001876
#> 34: RV G02967907 GDC-0077 PI3K-A G02001876
#> 35: GR G02967907 GDC-0077 PI3K-A G02001876
#> 36: GR G02967907 GDC-0077 PI3K-A G02001876
#> 37: RV G02967907 GDC-0077 PI3K-A G02001876
#> 38: GR G02967907 GDC-0077 PI3K-A G02001876
#> 39: RV G02967907 GDC-0077 PI3K-A G02001876
#> 40: GR G02967907 GDC-0077 PI3K-A G02001876
#> 41: RV G02967907 GDC-0077 PI3K-A G02001876
#> 42: RV G02967907 GDC-0077 PI3K-A G02001876
#> 43: GR G02967907 GDC-0077 PI3K-A G02001876
#> 44: RV G02967907 GDC-0077 PI3K-A G02001876
#> 45: GR G02967907 GDC-0077 PI3K-A G02001876
#> 46: RV G02967907 GDC-0077 PI3K-A G02001876
#> 47: GR G02967907 GDC-0077 PI3K-A G02001876
#> 48: RV G02967907 GDC-0077 PI3K-A G02001876
#> 49: GR G02967907 GDC-0077 PI3K-A G02001876
#> 50: GR G02967907 GDC-0077 PI3K-A G02001876
#> 51: RV G02967907 GDC-0077 PI3K-A G02001876
#> 52: GR G02967907 GDC-0077 PI3K-A G02001876
#> 53: RV G02967907 GDC-0077 PI3K-A G02001876
#> 54: GR G02967907 GDC-0077 PI3K-A G02001876
#> 55: RV G02967907 GDC-0077 PI3K-A G02001876
#> 56: GR G02967907 GDC-0077 PI3K-A G02001876
#> 57: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 58: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 59: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 60: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 61: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 62: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 63: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 64: RV G02967907 GDC-0077 PI3K-A G02001876
#> 65: RV G02967907 GDC-0077 PI3K-A G02001876
#> 66: RV G02967907 GDC-0077 PI3K-A G02001876
#> 67: RV G02967907 GDC-0077 PI3K-A G02001876
#> 68: GR G02967907 GDC-0077 PI3K-A G02001876
#> 69: RV G02967907 GDC-0077 PI3K-A G02001876
#> 70: RV G02967907 GDC-0077 PI3K-A G02001876
#> normalization_type i.Gnumber i.DrugName i.drug_moa i.Gnumber_2
#> i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid
#> 1: <NA> <NA> <NA> <NA> 168 CL129757
#> 2: <NA> <NA> <NA> <NA> 168 CL130742
#> 3: <NA> <NA> <NA> <NA> 168 CL131873
#> 4: <NA> <NA> <NA> <NA> 168 CL131903
#> 5: <NA> <NA> <NA> <NA> 168 CL130218
#> 6: <NA> <NA> <NA> <NA> 168 CL131438
#> 7: <NA> <NA> <NA> <NA> 168 CL131891
#> 8: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 9: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 10: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 11: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 12: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 13: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 14: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 15: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 16: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 17: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 18: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 19: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 20: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 21: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 22: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 23: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 24: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 25: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 26: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 27: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 28: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 29: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 30: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 31: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 32: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 33: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 34: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 35: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 36: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 37: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 38: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 39: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 40: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 41: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 42: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 43: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 44: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 45: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 46: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 47: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 48: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 49: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 50: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 51: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 52: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 53: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 54: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 55: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 56: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 57: <NA> <NA> <NA> <NA> 168 CL129757
#> 58: <NA> <NA> <NA> <NA> 168 CL130742
#> 59: <NA> <NA> <NA> <NA> 168 CL131873
#> 60: <NA> <NA> <NA> <NA> 168 CL131903
#> 61: <NA> <NA> <NA> <NA> 168 CL130218
#> 62: <NA> <NA> <NA> <NA> 168 CL131438
#> 63: <NA> <NA> <NA> <NA> 168 CL131891
#> 64: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 65: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 66: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 67: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 68: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 69: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 70: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid
#> i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: MCF-7 Breast MCF-7 unknown
#> 2: T-47D Breast T-47D unknown
#> 3: HCC1428 Breast HCC1428 unknown
#> 4: BT-483 Breast BT-483 unknown
#> 5: BT-474 Breast BT-474 unknown
#> 6: CAMA-1 Breast CAMA-1 unknown
#> 7: EFM-19 Breast EFM-19 unknown
#> 8: MCF-7 Breast MCF-7 unknown
#> 9: MCF-7 Breast MCF-7 unknown
#> 10: MCF-7 Breast MCF-7 unknown
#> 11: MCF-7 Breast MCF-7 unknown
#> 12: MCF-7 Breast MCF-7 unknown
#> 13: MCF-7 Breast MCF-7 unknown
#> 14: MCF-7 Breast MCF-7 unknown
#> 15: BT-474 Breast BT-474 unknown
#> 16: BT-474 Breast BT-474 unknown
#> 17: BT-474 Breast BT-474 unknown
#> 18: BT-474 Breast BT-474 unknown
#> 19: BT-474 Breast BT-474 unknown
#> 20: BT-474 Breast BT-474 unknown
#> 21: BT-474 Breast BT-474 unknown
#> 22: T-47D Breast T-47D unknown
#> 23: T-47D Breast T-47D unknown
#> 24: T-47D Breast T-47D unknown
#> 25: T-47D Breast T-47D unknown
#> 26: T-47D Breast T-47D unknown
#> 27: T-47D Breast T-47D unknown
#> 28: T-47D Breast T-47D unknown
#> 29: CAMA-1 Breast CAMA-1 unknown
#> 30: CAMA-1 Breast CAMA-1 unknown
#> 31: CAMA-1 Breast CAMA-1 unknown
#> 32: CAMA-1 Breast CAMA-1 unknown
#> 33: CAMA-1 Breast CAMA-1 unknown
#> 34: CAMA-1 Breast CAMA-1 unknown
#> 35: CAMA-1 Breast CAMA-1 unknown
#> 36: HCC1428 Breast HCC1428 unknown
#> 37: HCC1428 Breast HCC1428 unknown
#> 38: HCC1428 Breast HCC1428 unknown
#> 39: HCC1428 Breast HCC1428 unknown
#> 40: HCC1428 Breast HCC1428 unknown
#> 41: HCC1428 Breast HCC1428 unknown
#> 42: HCC1428 Breast HCC1428 unknown
#> 43: EFM-19 Breast EFM-19 unknown
#> 44: EFM-19 Breast EFM-19 unknown
#> 45: EFM-19 Breast EFM-19 unknown
#> 46: EFM-19 Breast EFM-19 unknown
#> 47: EFM-19 Breast EFM-19 unknown
#> 48: EFM-19 Breast EFM-19 unknown
#> 49: EFM-19 Breast EFM-19 unknown
#> 50: BT-483 Breast BT-483 unknown
#> 51: BT-483 Breast BT-483 unknown
#> 52: BT-483 Breast BT-483 unknown
#> 53: BT-483 Breast BT-483 unknown
#> 54: BT-483 Breast BT-483 unknown
#> 55: BT-483 Breast BT-483 unknown
#> 56: BT-483 Breast BT-483 unknown
#> 57: MCF-7 Breast MCF-7 unknown
#> 58: T-47D Breast T-47D unknown
#> 59: HCC1428 Breast HCC1428 unknown
#> 60: BT-483 Breast BT-483 unknown
#> 61: BT-474 Breast BT-474 unknown
#> 62: CAMA-1 Breast CAMA-1 unknown
#> 63: EFM-19 Breast EFM-19 unknown
#> 64: MCF-7 Breast MCF-7 unknown
#> 65: BT-474 Breast BT-474 unknown
#> 66: T-47D Breast T-47D unknown
#> 67: CAMA-1 Breast CAMA-1 unknown
#> 68: HCC1428 Breast HCC1428 unknown
#> 69: EFM-19 Breast EFM-19 unknown
#> 70: BT-483 Breast BT-483 unknown
#> i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 60
#> 3: 74
#> 4: 130
#> 5: 70
#> 6: 53
#> 7: 64
#> 8: 30
#> 9: 30
#> 10: 30
#> 11: 30
#> 12: 30
#> 13: 30
#> 14: 30
#> 15: 70
#> 16: 70
#> 17: 70
#> 18: 70
#> 19: 70
#> 20: 70
#> 21: 70
#> 22: 60
#> 23: 60
#> 24: 60
#> 25: 60
#> 26: 60
#> 27: 60
#> 28: 60
#> 29: 53
#> 30: 53
#> 31: 53
#> 32: 53
#> 33: 53
#> 34: 53
#> 35: 53
#> 36: 74
#> 37: 74
#> 38: 74
#> 39: 74
#> 40: 74
#> 41: 74
#> 42: 74
#> 43: 64
#> 44: 64
#> 45: 64
#> 46: 64
#> 47: 64
#> 48: 64
#> 49: 64
#> 50: 130
#> 51: 130
#> 52: 130
#> 53: 130
#> 54: 130
#> 55: 130
#> 56: 130
#> 57: 30
#> 58: 60
#> 59: 74
#> 60: 130
#> 61: 70
#> 62: 53
#> 63: 64
#> 64: 30
#> 65: 70
#> 66: 60
#> 67: 53
#> 68: 74
#> 69: 64
#> 70: 130
#> i.ReferenceDivisionTime
#>
#> $BlissExcess
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: <NA>
#> 16: <NA>
#> 17: <NA>
#> 18: <NA>
#> 19: <NA>
#> 20: <NA>
#> 21: <NA>
#> 22: <NA>
#> 23: <NA>
#> 24: <NA>
#> 25: <NA>
#> 26: <NA>
#> 27: <NA>
#> 28: <NA>
#> 29: <NA>
#> 30: <NA>
#> 31: <NA>
#> 32: <NA>
#> 33: <NA>
#> 34: <NA>
#> 35: <NA>
#> 36: <NA>
#> 37: <NA>
#> 38: <NA>
#> 39: <NA>
#> 40: <NA>
#> 41: <NA>
#> 42: <NA>
#> 43: <NA>
#> 44: <NA>
#> 45: <NA>
#> 46: <NA>
#> 47: <NA>
#> 48: <NA>
#> 49: <NA>
#> 50: <NA>
#> 51: <NA>
#> 52: <NA>
#> 53: <NA>
#> 54: <NA>
#> 55: <NA>
#> 56: <NA>
#> 57: G02001876_Palbociclib_CDK4|CDK6_168
#> 58: G02001876_Palbociclib_CDK4|CDK6_168
#> 59: G02001876_Palbociclib_CDK4|CDK6_168
#> 60: G02001876_Palbociclib_CDK4|CDK6_168
#> 61: G02967907_GDC-0077_PI3K-A_168
#> 62: G02967907_GDC-0077_PI3K-A_168
#> 63: G02967907_GDC-0077_PI3K-A_168
#> 64: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 65: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 66: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 67: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 68: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 69: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 70: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: <NA> <NA> <NA>
#> 16: <NA> <NA> <NA>
#> 17: <NA> <NA> <NA>
#> 18: <NA> <NA> <NA>
#> 19: <NA> <NA> <NA>
#> 20: <NA> <NA> <NA>
#> 21: <NA> <NA> <NA>
#> 22: <NA> <NA> <NA>
#> 23: <NA> <NA> <NA>
#> 24: <NA> <NA> <NA>
#> 25: <NA> <NA> <NA>
#> 26: <NA> <NA> <NA>
#> 27: <NA> <NA> <NA>
#> 28: <NA> <NA> <NA>
#> 29: <NA> <NA> <NA>
#> 30: <NA> <NA> <NA>
#> 31: <NA> <NA> <NA>
#> 32: <NA> <NA> <NA>
#> 33: <NA> <NA> <NA>
#> 34: <NA> <NA> <NA>
#> 35: <NA> <NA> <NA>
#> 36: <NA> <NA> <NA>
#> 37: <NA> <NA> <NA>
#> 38: <NA> <NA> <NA>
#> 39: <NA> <NA> <NA>
#> 40: <NA> <NA> <NA>
#> 41: <NA> <NA> <NA>
#> 42: <NA> <NA> <NA>
#> 43: <NA> <NA> <NA>
#> 44: <NA> <NA> <NA>
#> 45: <NA> <NA> <NA>
#> 46: <NA> <NA> <NA>
#> 47: <NA> <NA> <NA>
#> 48: <NA> <NA> <NA>
#> 49: <NA> <NA> <NA>
#> 50: <NA> <NA> <NA>
#> 51: <NA> <NA> <NA>
#> 52: <NA> <NA> <NA>
#> 53: <NA> <NA> <NA>
#> 54: <NA> <NA> <NA>
#> 55: <NA> <NA> <NA>
#> 56: <NA> <NA> <NA>
#> 57: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 58: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 59: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 60: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 61: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 62: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 63: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 64: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 65: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 66: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 67: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 68: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 69: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 70: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 16: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 17: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 18: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 19: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 20: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 21: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 22: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 23: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 24: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 25: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 26: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 27: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 28: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 29: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 30: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 31: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 32: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 33: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 34: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 35: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 36: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 37: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 38: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 39: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 40: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 41: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 42: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 43: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 44: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 45: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 46: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 47: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 48: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 49: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 50: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 51: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 52: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 53: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 54: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 55: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 56: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 57: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 58: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 59: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 60: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 61: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 62: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 63: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 64: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 65: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 66: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 67: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 68: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 69: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 70: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: <NA> NA <NA> <NA> <NA>
#> 16: <NA> NA <NA> <NA> <NA>
#> 17: <NA> NA <NA> <NA> <NA>
#> 18: <NA> NA <NA> <NA> <NA>
#> 19: <NA> NA <NA> <NA> <NA>
#> 20: <NA> NA <NA> <NA> <NA>
#> 21: <NA> NA <NA> <NA> <NA>
#> 22: <NA> NA <NA> <NA> <NA>
#> 23: <NA> NA <NA> <NA> <NA>
#> 24: <NA> NA <NA> <NA> <NA>
#> 25: <NA> NA <NA> <NA> <NA>
#> 26: <NA> NA <NA> <NA> <NA>
#> 27: <NA> NA <NA> <NA> <NA>
#> 28: <NA> NA <NA> <NA> <NA>
#> 29: <NA> NA <NA> <NA> <NA>
#> 30: <NA> NA <NA> <NA> <NA>
#> 31: <NA> NA <NA> <NA> <NA>
#> 32: <NA> NA <NA> <NA> <NA>
#> 33: <NA> NA <NA> <NA> <NA>
#> 34: <NA> NA <NA> <NA> <NA>
#> 35: <NA> NA <NA> <NA> <NA>
#> 36: <NA> NA <NA> <NA> <NA>
#> 37: <NA> NA <NA> <NA> <NA>
#> 38: <NA> NA <NA> <NA> <NA>
#> 39: <NA> NA <NA> <NA> <NA>
#> 40: <NA> NA <NA> <NA> <NA>
#> 41: <NA> NA <NA> <NA> <NA>
#> 42: <NA> NA <NA> <NA> <NA>
#> 43: <NA> NA <NA> <NA> <NA>
#> 44: <NA> NA <NA> <NA> <NA>
#> 45: <NA> NA <NA> <NA> <NA>
#> 46: <NA> NA <NA> <NA> <NA>
#> 47: <NA> NA <NA> <NA> <NA>
#> 48: <NA> NA <NA> <NA> <NA>
#> 49: <NA> NA <NA> <NA> <NA>
#> 50: <NA> NA <NA> <NA> <NA>
#> 51: <NA> NA <NA> <NA> <NA>
#> 52: <NA> NA <NA> <NA> <NA>
#> 53: <NA> NA <NA> <NA> <NA>
#> 54: <NA> NA <NA> <NA> <NA>
#> 55: <NA> NA <NA> <NA> <NA>
#> 56: <NA> NA <NA> <NA> <NA>
#> 57: MCF-7 30 Breast CL129757 MCF-7
#> 58: T-47D 60 Breast CL130742 T-47D
#> 59: HCC1428 74 Breast CL131873 HCC1428
#> 60: BT-483 130 Breast CL131903 BT-483
#> 61: BT-474 70 Breast CL130218 BT-474
#> 62: CAMA-1 53 Breast CL131438 CAMA-1
#> 63: EFM-19 64 Breast CL131891 EFM-19
#> 64: MCF-7 30 Breast CL129757 MCF-7
#> 65: BT-474 70 Breast CL130218 BT-474
#> 66: T-47D 60 Breast CL130742 T-47D
#> 67: CAMA-1 53 Breast CL131438 CAMA-1
#> 68: HCC1428 74 Breast CL131873 HCC1428
#> 69: EFM-19 64 Breast CL131891 EFM-19
#> 70: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type Concentration Concentration_2 x
#> 1: <NA> single-agent NA NA NA
#> 2: <NA> single-agent NA NA NA
#> 3: <NA> single-agent NA NA NA
#> 4: <NA> single-agent NA NA NA
#> 5: <NA> single-agent NA NA NA
#> 6: <NA> single-agent NA NA NA
#> 7: <NA> single-agent NA NA NA
#> 8: <NA> matrix 0.0000000 0.0 NA
#> 9: <NA> matrix 0.0000000 0.0 NA
#> 10: <NA> matrix 0.0000000 0.1 NA
#> 11: <NA> matrix 0.0000000 0.1 NA
#> 12: <NA> matrix 0.1499999 0.0 NA
#> 13: <NA> matrix 0.1499999 0.0 NA
#> 14: <NA> matrix 0.1499999 0.1 0.04879045
#> 15: <NA> matrix 0.0000000 0.0 NA
#> 16: <NA> matrix 0.0000000 0.0 NA
#> 17: <NA> matrix 0.0000000 0.1 NA
#> 18: <NA> matrix 0.0000000 0.1 NA
#> 19: <NA> matrix 0.1499999 0.0 NA
#> 20: <NA> matrix 0.1499999 0.0 NA
#> 21: <NA> matrix 0.1499999 0.1 0.15247017
#> 22: <NA> matrix 0.0000000 0.0 NA
#> 23: <NA> matrix 0.0000000 0.0 NA
#> 24: <NA> matrix 0.0000000 0.1 NA
#> 25: <NA> matrix 0.0000000 0.1 NA
#> 26: <NA> matrix 0.1499999 0.0 NA
#> 27: <NA> matrix 0.1499999 0.0 NA
#> 28: <NA> matrix 0.1499999 0.1 0.03244561
#> 29: <NA> matrix 0.0000000 0.0 NA
#> 30: <NA> matrix 0.0000000 0.0 NA
#> 31: <NA> matrix 0.0000000 0.1 NA
#> 32: <NA> matrix 0.0000000 0.1 NA
#> 33: <NA> matrix 0.1499999 0.0 NA
#> 34: <NA> matrix 0.1499999 0.0 NA
#> 35: <NA> matrix 0.1499999 0.1 -0.04708806
#> 36: <NA> matrix 0.0000000 0.0 NA
#> 37: <NA> matrix 0.0000000 0.0 NA
#> 38: <NA> matrix 0.0000000 0.1 NA
#> 39: <NA> matrix 0.0000000 0.1 NA
#> 40: <NA> matrix 0.1499999 0.0 NA
#> 41: <NA> matrix 0.1499999 0.0 NA
#> 42: <NA> matrix 0.1499999 0.1 NA
#> 43: <NA> matrix 0.0000000 0.0 NA
#> 44: <NA> matrix 0.0000000 0.0 NA
#> 45: <NA> matrix 0.0000000 0.1 NA
#> 46: <NA> matrix 0.0000000 0.1 NA
#> 47: <NA> matrix 0.1499999 0.0 NA
#> 48: <NA> matrix 0.1499999 0.0 NA
#> 49: <NA> matrix 0.1499999 0.1 NA
#> 50: <NA> matrix 0.0000000 0.0 NA
#> 51: <NA> matrix 0.0000000 0.0 NA
#> 52: <NA> matrix 0.0000000 0.1 NA
#> 53: <NA> matrix 0.0000000 0.1 NA
#> 54: <NA> matrix 0.1499999 0.0 NA
#> 55: <NA> matrix 0.1499999 0.0 NA
#> 56: <NA> matrix 0.1499999 0.1 0.01476427
#> 57: unknown single-agent NA NA NA
#> 58: unknown single-agent NA NA NA
#> 59: unknown single-agent NA NA NA
#> 60: unknown single-agent NA NA NA
#> 61: unknown single-agent NA NA NA
#> 62: unknown single-agent NA NA NA
#> 63: unknown single-agent NA NA NA
#> 64: unknown matrix 0.1499999 0.1 0.25858907
#> 65: unknown matrix 0.1499999 0.1 0.21241078
#> 66: unknown matrix 0.1499999 0.1 0.30496602
#> 67: unknown matrix 0.1499999 0.1 -0.02970403
#> 68: unknown matrix 0.1499999 0.1 NA
#> 69: unknown matrix 0.1499999 0.1 0.03246174
#> 70: unknown matrix 0.1499999 0.1 0.45904274
#> subtype data_type Concentration Concentration_2 x
#> normalization_type i.Gnumber i.DrugName i.drug_moa i.Gnumber_2
#> 1: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 2: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 3: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 4: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 5: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 6: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 7: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 8: GR G02967907 GDC-0077 PI3K-A G02001876
#> 9: RV G02967907 GDC-0077 PI3K-A G02001876
#> 10: GR G02967907 GDC-0077 PI3K-A G02001876
#> 11: RV G02967907 GDC-0077 PI3K-A G02001876
#> 12: GR G02967907 GDC-0077 PI3K-A G02001876
#> 13: RV G02967907 GDC-0077 PI3K-A G02001876
#> 14: RV G02967907 GDC-0077 PI3K-A G02001876
#> 15: GR G02967907 GDC-0077 PI3K-A G02001876
#> 16: RV G02967907 GDC-0077 PI3K-A G02001876
#> 17: GR G02967907 GDC-0077 PI3K-A G02001876
#> 18: RV G02967907 GDC-0077 PI3K-A G02001876
#> 19: GR G02967907 GDC-0077 PI3K-A G02001876
#> 20: RV G02967907 GDC-0077 PI3K-A G02001876
#> 21: RV G02967907 GDC-0077 PI3K-A G02001876
#> 22: GR G02967907 GDC-0077 PI3K-A G02001876
#> 23: RV G02967907 GDC-0077 PI3K-A G02001876
#> 24: GR G02967907 GDC-0077 PI3K-A G02001876
#> 25: RV G02967907 GDC-0077 PI3K-A G02001876
#> 26: GR G02967907 GDC-0077 PI3K-A G02001876
#> 27: RV G02967907 GDC-0077 PI3K-A G02001876
#> 28: RV G02967907 GDC-0077 PI3K-A G02001876
#> 29: GR G02967907 GDC-0077 PI3K-A G02001876
#> 30: RV G02967907 GDC-0077 PI3K-A G02001876
#> 31: GR G02967907 GDC-0077 PI3K-A G02001876
#> 32: RV G02967907 GDC-0077 PI3K-A G02001876
#> 33: GR G02967907 GDC-0077 PI3K-A G02001876
#> 34: RV G02967907 GDC-0077 PI3K-A G02001876
#> 35: RV G02967907 GDC-0077 PI3K-A G02001876
#> 36: GR G02967907 GDC-0077 PI3K-A G02001876
#> 37: RV G02967907 GDC-0077 PI3K-A G02001876
#> 38: GR G02967907 GDC-0077 PI3K-A G02001876
#> 39: RV G02967907 GDC-0077 PI3K-A G02001876
#> 40: GR G02967907 GDC-0077 PI3K-A G02001876
#> 41: RV G02967907 GDC-0077 PI3K-A G02001876
#> 42: GR G02967907 GDC-0077 PI3K-A G02001876
#> 43: GR G02967907 GDC-0077 PI3K-A G02001876
#> 44: RV G02967907 GDC-0077 PI3K-A G02001876
#> 45: GR G02967907 GDC-0077 PI3K-A G02001876
#> 46: RV G02967907 GDC-0077 PI3K-A G02001876
#> 47: GR G02967907 GDC-0077 PI3K-A G02001876
#> 48: RV G02967907 GDC-0077 PI3K-A G02001876
#> 49: GR G02967907 GDC-0077 PI3K-A G02001876
#> 50: GR G02967907 GDC-0077 PI3K-A G02001876
#> 51: RV G02967907 GDC-0077 PI3K-A G02001876
#> 52: GR G02967907 GDC-0077 PI3K-A G02001876
#> 53: RV G02967907 GDC-0077 PI3K-A G02001876
#> 54: GR G02967907 GDC-0077 PI3K-A G02001876
#> 55: RV G02967907 GDC-0077 PI3K-A G02001876
#> 56: RV G02967907 GDC-0077 PI3K-A G02001876
#> 57: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 58: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 59: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 60: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 61: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 62: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 63: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 64: GR G02967907 GDC-0077 PI3K-A G02001876
#> 65: GR G02967907 GDC-0077 PI3K-A G02001876
#> 66: GR G02967907 GDC-0077 PI3K-A G02001876
#> 67: GR G02967907 GDC-0077 PI3K-A G02001876
#> 68: RV G02967907 GDC-0077 PI3K-A G02001876
#> 69: RV G02967907 GDC-0077 PI3K-A G02001876
#> 70: GR G02967907 GDC-0077 PI3K-A G02001876
#> normalization_type i.Gnumber i.DrugName i.drug_moa i.Gnumber_2
#> i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid
#> 1: <NA> <NA> <NA> <NA> 168 CL129757
#> 2: <NA> <NA> <NA> <NA> 168 CL130742
#> 3: <NA> <NA> <NA> <NA> 168 CL131873
#> 4: <NA> <NA> <NA> <NA> 168 CL131903
#> 5: <NA> <NA> <NA> <NA> 168 CL130218
#> 6: <NA> <NA> <NA> <NA> 168 CL131438
#> 7: <NA> <NA> <NA> <NA> 168 CL131891
#> 8: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 9: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 10: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 11: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 12: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 13: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 14: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 15: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 16: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 17: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 18: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 19: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 20: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 21: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 22: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 23: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 24: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 25: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 26: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 27: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 28: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 29: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 30: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 31: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 32: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 33: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 34: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 35: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 36: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 37: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 38: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 39: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 40: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 41: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 42: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 43: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 44: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 45: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 46: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 47: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 48: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 49: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 50: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 51: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 52: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 53: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 54: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 55: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 56: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 57: <NA> <NA> <NA> <NA> 168 CL129757
#> 58: <NA> <NA> <NA> <NA> 168 CL130742
#> 59: <NA> <NA> <NA> <NA> 168 CL131873
#> 60: <NA> <NA> <NA> <NA> 168 CL131903
#> 61: <NA> <NA> <NA> <NA> 168 CL130218
#> 62: <NA> <NA> <NA> <NA> 168 CL131438
#> 63: <NA> <NA> <NA> <NA> 168 CL131891
#> 64: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 65: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 66: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 67: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 68: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 69: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 70: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid
#> i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: MCF-7 Breast MCF-7 unknown
#> 2: T-47D Breast T-47D unknown
#> 3: HCC1428 Breast HCC1428 unknown
#> 4: BT-483 Breast BT-483 unknown
#> 5: BT-474 Breast BT-474 unknown
#> 6: CAMA-1 Breast CAMA-1 unknown
#> 7: EFM-19 Breast EFM-19 unknown
#> 8: MCF-7 Breast MCF-7 unknown
#> 9: MCF-7 Breast MCF-7 unknown
#> 10: MCF-7 Breast MCF-7 unknown
#> 11: MCF-7 Breast MCF-7 unknown
#> 12: MCF-7 Breast MCF-7 unknown
#> 13: MCF-7 Breast MCF-7 unknown
#> 14: MCF-7 Breast MCF-7 unknown
#> 15: BT-474 Breast BT-474 unknown
#> 16: BT-474 Breast BT-474 unknown
#> 17: BT-474 Breast BT-474 unknown
#> 18: BT-474 Breast BT-474 unknown
#> 19: BT-474 Breast BT-474 unknown
#> 20: BT-474 Breast BT-474 unknown
#> 21: BT-474 Breast BT-474 unknown
#> 22: T-47D Breast T-47D unknown
#> 23: T-47D Breast T-47D unknown
#> 24: T-47D Breast T-47D unknown
#> 25: T-47D Breast T-47D unknown
#> 26: T-47D Breast T-47D unknown
#> 27: T-47D Breast T-47D unknown
#> 28: T-47D Breast T-47D unknown
#> 29: CAMA-1 Breast CAMA-1 unknown
#> 30: CAMA-1 Breast CAMA-1 unknown
#> 31: CAMA-1 Breast CAMA-1 unknown
#> 32: CAMA-1 Breast CAMA-1 unknown
#> 33: CAMA-1 Breast CAMA-1 unknown
#> 34: CAMA-1 Breast CAMA-1 unknown
#> 35: CAMA-1 Breast CAMA-1 unknown
#> 36: HCC1428 Breast HCC1428 unknown
#> 37: HCC1428 Breast HCC1428 unknown
#> 38: HCC1428 Breast HCC1428 unknown
#> 39: HCC1428 Breast HCC1428 unknown
#> 40: HCC1428 Breast HCC1428 unknown
#> 41: HCC1428 Breast HCC1428 unknown
#> 42: HCC1428 Breast HCC1428 unknown
#> 43: EFM-19 Breast EFM-19 unknown
#> 44: EFM-19 Breast EFM-19 unknown
#> 45: EFM-19 Breast EFM-19 unknown
#> 46: EFM-19 Breast EFM-19 unknown
#> 47: EFM-19 Breast EFM-19 unknown
#> 48: EFM-19 Breast EFM-19 unknown
#> 49: EFM-19 Breast EFM-19 unknown
#> 50: BT-483 Breast BT-483 unknown
#> 51: BT-483 Breast BT-483 unknown
#> 52: BT-483 Breast BT-483 unknown
#> 53: BT-483 Breast BT-483 unknown
#> 54: BT-483 Breast BT-483 unknown
#> 55: BT-483 Breast BT-483 unknown
#> 56: BT-483 Breast BT-483 unknown
#> 57: MCF-7 Breast MCF-7 unknown
#> 58: T-47D Breast T-47D unknown
#> 59: HCC1428 Breast HCC1428 unknown
#> 60: BT-483 Breast BT-483 unknown
#> 61: BT-474 Breast BT-474 unknown
#> 62: CAMA-1 Breast CAMA-1 unknown
#> 63: EFM-19 Breast EFM-19 unknown
#> 64: MCF-7 Breast MCF-7 unknown
#> 65: BT-474 Breast BT-474 unknown
#> 66: T-47D Breast T-47D unknown
#> 67: CAMA-1 Breast CAMA-1 unknown
#> 68: HCC1428 Breast HCC1428 unknown
#> 69: EFM-19 Breast EFM-19 unknown
#> 70: BT-483 Breast BT-483 unknown
#> i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 60
#> 3: 74
#> 4: 130
#> 5: 70
#> 6: 53
#> 7: 64
#> 8: 30
#> 9: 30
#> 10: 30
#> 11: 30
#> 12: 30
#> 13: 30
#> 14: 30
#> 15: 70
#> 16: 70
#> 17: 70
#> 18: 70
#> 19: 70
#> 20: 70
#> 21: 70
#> 22: 60
#> 23: 60
#> 24: 60
#> 25: 60
#> 26: 60
#> 27: 60
#> 28: 60
#> 29: 53
#> 30: 53
#> 31: 53
#> 32: 53
#> 33: 53
#> 34: 53
#> 35: 53
#> 36: 74
#> 37: 74
#> 38: 74
#> 39: 74
#> 40: 74
#> 41: 74
#> 42: 74
#> 43: 64
#> 44: 64
#> 45: 64
#> 46: 64
#> 47: 64
#> 48: 64
#> 49: 64
#> 50: 130
#> 51: 130
#> 52: 130
#> 53: 130
#> 54: 130
#> 55: 130
#> 56: 130
#> 57: 30
#> 58: 60
#> 59: 74
#> 60: 130
#> 61: 70
#> 62: 53
#> 63: 64
#> 64: 30
#> 65: 70
#> 66: 60
#> 67: 53
#> 68: 74
#> 69: 64
#> 70: 130
#> i.ReferenceDivisionTime
#>
#> $HSAExcess
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: <NA>
#> 16: <NA>
#> 17: <NA>
#> 18: <NA>
#> 19: <NA>
#> 20: <NA>
#> 21: <NA>
#> 22: <NA>
#> 23: <NA>
#> 24: <NA>
#> 25: <NA>
#> 26: <NA>
#> 27: <NA>
#> 28: <NA>
#> 29: <NA>
#> 30: <NA>
#> 31: <NA>
#> 32: <NA>
#> 33: <NA>
#> 34: <NA>
#> 35: <NA>
#> 36: <NA>
#> 37: <NA>
#> 38: <NA>
#> 39: <NA>
#> 40: <NA>
#> 41: <NA>
#> 42: <NA>
#> 43: <NA>
#> 44: <NA>
#> 45: <NA>
#> 46: <NA>
#> 47: <NA>
#> 48: <NA>
#> 49: <NA>
#> 50: <NA>
#> 51: <NA>
#> 52: <NA>
#> 53: <NA>
#> 54: <NA>
#> 55: <NA>
#> 56: <NA>
#> 57: G02001876_Palbociclib_CDK4|CDK6_168
#> 58: G02001876_Palbociclib_CDK4|CDK6_168
#> 59: G02001876_Palbociclib_CDK4|CDK6_168
#> 60: G02001876_Palbociclib_CDK4|CDK6_168
#> 61: G02967907_GDC-0077_PI3K-A_168
#> 62: G02967907_GDC-0077_PI3K-A_168
#> 63: G02967907_GDC-0077_PI3K-A_168
#> 64: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 65: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 66: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 67: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 68: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 69: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 70: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: <NA> <NA> <NA>
#> 16: <NA> <NA> <NA>
#> 17: <NA> <NA> <NA>
#> 18: <NA> <NA> <NA>
#> 19: <NA> <NA> <NA>
#> 20: <NA> <NA> <NA>
#> 21: <NA> <NA> <NA>
#> 22: <NA> <NA> <NA>
#> 23: <NA> <NA> <NA>
#> 24: <NA> <NA> <NA>
#> 25: <NA> <NA> <NA>
#> 26: <NA> <NA> <NA>
#> 27: <NA> <NA> <NA>
#> 28: <NA> <NA> <NA>
#> 29: <NA> <NA> <NA>
#> 30: <NA> <NA> <NA>
#> 31: <NA> <NA> <NA>
#> 32: <NA> <NA> <NA>
#> 33: <NA> <NA> <NA>
#> 34: <NA> <NA> <NA>
#> 35: <NA> <NA> <NA>
#> 36: <NA> <NA> <NA>
#> 37: <NA> <NA> <NA>
#> 38: <NA> <NA> <NA>
#> 39: <NA> <NA> <NA>
#> 40: <NA> <NA> <NA>
#> 41: <NA> <NA> <NA>
#> 42: <NA> <NA> <NA>
#> 43: <NA> <NA> <NA>
#> 44: <NA> <NA> <NA>
#> 45: <NA> <NA> <NA>
#> 46: <NA> <NA> <NA>
#> 47: <NA> <NA> <NA>
#> 48: <NA> <NA> <NA>
#> 49: <NA> <NA> <NA>
#> 50: <NA> <NA> <NA>
#> 51: <NA> <NA> <NA>
#> 52: <NA> <NA> <NA>
#> 53: <NA> <NA> <NA>
#> 54: <NA> <NA> <NA>
#> 55: <NA> <NA> <NA>
#> 56: <NA> <NA> <NA>
#> 57: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 58: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 59: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 60: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 61: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 62: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 63: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 64: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 65: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 66: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 67: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 68: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 69: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 70: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 16: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 17: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 18: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 19: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 20: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 21: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 22: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 23: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 24: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 25: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 26: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 27: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 28: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 29: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 30: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 31: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 32: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 33: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 34: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 35: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 36: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 37: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 38: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 39: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 40: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 41: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 42: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 43: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 44: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 45: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 46: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 47: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 48: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 49: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 50: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 51: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 52: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 53: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 54: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 55: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 56: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 57: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 58: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 59: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 60: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 61: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 62: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 63: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 64: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 65: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 66: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 67: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 68: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 69: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 70: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: <NA> NA <NA> <NA> <NA>
#> 16: <NA> NA <NA> <NA> <NA>
#> 17: <NA> NA <NA> <NA> <NA>
#> 18: <NA> NA <NA> <NA> <NA>
#> 19: <NA> NA <NA> <NA> <NA>
#> 20: <NA> NA <NA> <NA> <NA>
#> 21: <NA> NA <NA> <NA> <NA>
#> 22: <NA> NA <NA> <NA> <NA>
#> 23: <NA> NA <NA> <NA> <NA>
#> 24: <NA> NA <NA> <NA> <NA>
#> 25: <NA> NA <NA> <NA> <NA>
#> 26: <NA> NA <NA> <NA> <NA>
#> 27: <NA> NA <NA> <NA> <NA>
#> 28: <NA> NA <NA> <NA> <NA>
#> 29: <NA> NA <NA> <NA> <NA>
#> 30: <NA> NA <NA> <NA> <NA>
#> 31: <NA> NA <NA> <NA> <NA>
#> 32: <NA> NA <NA> <NA> <NA>
#> 33: <NA> NA <NA> <NA> <NA>
#> 34: <NA> NA <NA> <NA> <NA>
#> 35: <NA> NA <NA> <NA> <NA>
#> 36: <NA> NA <NA> <NA> <NA>
#> 37: <NA> NA <NA> <NA> <NA>
#> 38: <NA> NA <NA> <NA> <NA>
#> 39: <NA> NA <NA> <NA> <NA>
#> 40: <NA> NA <NA> <NA> <NA>
#> 41: <NA> NA <NA> <NA> <NA>
#> 42: <NA> NA <NA> <NA> <NA>
#> 43: <NA> NA <NA> <NA> <NA>
#> 44: <NA> NA <NA> <NA> <NA>
#> 45: <NA> NA <NA> <NA> <NA>
#> 46: <NA> NA <NA> <NA> <NA>
#> 47: <NA> NA <NA> <NA> <NA>
#> 48: <NA> NA <NA> <NA> <NA>
#> 49: <NA> NA <NA> <NA> <NA>
#> 50: <NA> NA <NA> <NA> <NA>
#> 51: <NA> NA <NA> <NA> <NA>
#> 52: <NA> NA <NA> <NA> <NA>
#> 53: <NA> NA <NA> <NA> <NA>
#> 54: <NA> NA <NA> <NA> <NA>
#> 55: <NA> NA <NA> <NA> <NA>
#> 56: <NA> NA <NA> <NA> <NA>
#> 57: MCF-7 30 Breast CL129757 MCF-7
#> 58: T-47D 60 Breast CL130742 T-47D
#> 59: HCC1428 74 Breast CL131873 HCC1428
#> 60: BT-483 130 Breast CL131903 BT-483
#> 61: BT-474 70 Breast CL130218 BT-474
#> 62: CAMA-1 53 Breast CL131438 CAMA-1
#> 63: EFM-19 64 Breast CL131891 EFM-19
#> 64: MCF-7 30 Breast CL129757 MCF-7
#> 65: BT-474 70 Breast CL130218 BT-474
#> 66: T-47D 60 Breast CL130742 T-47D
#> 67: CAMA-1 53 Breast CL131438 CAMA-1
#> 68: HCC1428 74 Breast CL131873 HCC1428
#> 69: EFM-19 64 Breast CL131891 EFM-19
#> 70: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type Concentration Concentration_2 x
#> 1: <NA> single-agent NA NA NA
#> 2: <NA> single-agent NA NA NA
#> 3: <NA> single-agent NA NA NA
#> 4: <NA> single-agent NA NA NA
#> 5: <NA> single-agent NA NA NA
#> 6: <NA> single-agent NA NA NA
#> 7: <NA> single-agent NA NA NA
#> 8: <NA> matrix 0.0000000 0.0 NA
#> 9: <NA> matrix 0.0000000 0.0 NA
#> 10: <NA> matrix 0.0000000 0.1 NA
#> 11: <NA> matrix 0.0000000 0.1 NA
#> 12: <NA> matrix 0.1499999 0.0 NA
#> 13: <NA> matrix 0.1499999 0.0 NA
#> 14: <NA> matrix 0.1499999 0.1 0.2753005792
#> 15: <NA> matrix 0.0000000 0.0 NA
#> 16: <NA> matrix 0.0000000 0.0 NA
#> 17: <NA> matrix 0.0000000 0.1 NA
#> 18: <NA> matrix 0.0000000 0.1 NA
#> 19: <NA> matrix 0.1499999 0.0 NA
#> 20: <NA> matrix 0.1499999 0.0 NA
#> 21: <NA> matrix 0.1499999 0.1 0.2417955856
#> 22: <NA> matrix 0.0000000 0.0 NA
#> 23: <NA> matrix 0.0000000 0.0 NA
#> 24: <NA> matrix 0.0000000 0.1 NA
#> 25: <NA> matrix 0.0000000 0.1 NA
#> 26: <NA> matrix 0.1499999 0.0 NA
#> 27: <NA> matrix 0.1499999 0.0 NA
#> 28: <NA> matrix 0.1499999 0.1 0.1734790818
#> 29: <NA> matrix 0.0000000 0.0 NA
#> 30: <NA> matrix 0.0000000 0.0 NA
#> 31: <NA> matrix 0.0000000 0.1 NA
#> 32: <NA> matrix 0.0000000 0.1 NA
#> 33: <NA> matrix 0.1499999 0.0 NA
#> 34: <NA> matrix 0.1499999 0.0 NA
#> 35: <NA> matrix 0.1499999 0.1 -0.0007592983
#> 36: <NA> matrix 0.0000000 0.0 NA
#> 37: <NA> matrix 0.0000000 0.0 NA
#> 38: <NA> matrix 0.0000000 0.1 NA
#> 39: <NA> matrix 0.0000000 0.1 NA
#> 40: <NA> matrix 0.1499999 0.0 NA
#> 41: <NA> matrix 0.1499999 0.0 NA
#> 42: <NA> matrix 0.1499999 0.1 NaN
#> 43: <NA> matrix 0.0000000 0.0 NA
#> 44: <NA> matrix 0.0000000 0.0 NA
#> 45: <NA> matrix 0.0000000 0.1 NA
#> 46: <NA> matrix 0.0000000 0.1 NA
#> 47: <NA> matrix 0.1499999 0.0 NA
#> 48: <NA> matrix 0.1499999 0.0 NA
#> 49: <NA> matrix 0.1499999 0.1 NaN
#> 50: <NA> matrix 0.0000000 0.0 NA
#> 51: <NA> matrix 0.0000000 0.0 NA
#> 52: <NA> matrix 0.0000000 0.1 NA
#> 53: <NA> matrix 0.0000000 0.1 NA
#> 54: <NA> matrix 0.1499999 0.0 NA
#> 55: <NA> matrix 0.1499999 0.0 NA
#> 56: <NA> matrix 0.1499999 0.1 0.1366652981
#> 57: unknown single-agent NA NA NA
#> 58: unknown single-agent NA NA NA
#> 59: unknown single-agent NA NA NA
#> 60: unknown single-agent NA NA NA
#> 61: unknown single-agent NA NA NA
#> 62: unknown single-agent NA NA NA
#> 63: unknown single-agent NA NA NA
#> 64: unknown matrix 0.1499999 0.1 0.4841219683
#> 65: unknown matrix 0.1499999 0.1 0.3772046188
#> 66: unknown matrix 0.1499999 0.1 0.2921312256
#> 67: unknown matrix 0.1499999 0.1 -0.0002909946
#> 68: unknown matrix 0.1499999 0.1 NaN
#> 69: unknown matrix 0.1499999 0.1 0.1787512356
#> 70: unknown matrix 0.1499999 0.1 0.5922588391
#> subtype data_type Concentration Concentration_2 x
#> normalization_type i.Gnumber i.DrugName i.drug_moa i.Gnumber_2
#> 1: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 2: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 3: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 4: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 5: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 6: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 7: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 8: GR G02967907 GDC-0077 PI3K-A G02001876
#> 9: RV G02967907 GDC-0077 PI3K-A G02001876
#> 10: GR G02967907 GDC-0077 PI3K-A G02001876
#> 11: RV G02967907 GDC-0077 PI3K-A G02001876
#> 12: GR G02967907 GDC-0077 PI3K-A G02001876
#> 13: RV G02967907 GDC-0077 PI3K-A G02001876
#> 14: RV G02967907 GDC-0077 PI3K-A G02001876
#> 15: GR G02967907 GDC-0077 PI3K-A G02001876
#> 16: RV G02967907 GDC-0077 PI3K-A G02001876
#> 17: GR G02967907 GDC-0077 PI3K-A G02001876
#> 18: RV G02967907 GDC-0077 PI3K-A G02001876
#> 19: GR G02967907 GDC-0077 PI3K-A G02001876
#> 20: RV G02967907 GDC-0077 PI3K-A G02001876
#> 21: RV G02967907 GDC-0077 PI3K-A G02001876
#> 22: GR G02967907 GDC-0077 PI3K-A G02001876
#> 23: RV G02967907 GDC-0077 PI3K-A G02001876
#> 24: GR G02967907 GDC-0077 PI3K-A G02001876
#> 25: RV G02967907 GDC-0077 PI3K-A G02001876
#> 26: GR G02967907 GDC-0077 PI3K-A G02001876
#> 27: RV G02967907 GDC-0077 PI3K-A G02001876
#> 28: RV G02967907 GDC-0077 PI3K-A G02001876
#> 29: GR G02967907 GDC-0077 PI3K-A G02001876
#> 30: RV G02967907 GDC-0077 PI3K-A G02001876
#> 31: GR G02967907 GDC-0077 PI3K-A G02001876
#> 32: RV G02967907 GDC-0077 PI3K-A G02001876
#> 33: GR G02967907 GDC-0077 PI3K-A G02001876
#> 34: RV G02967907 GDC-0077 PI3K-A G02001876
#> 35: GR G02967907 GDC-0077 PI3K-A G02001876
#> 36: GR G02967907 GDC-0077 PI3K-A G02001876
#> 37: RV G02967907 GDC-0077 PI3K-A G02001876
#> 38: GR G02967907 GDC-0077 PI3K-A G02001876
#> 39: RV G02967907 GDC-0077 PI3K-A G02001876
#> 40: GR G02967907 GDC-0077 PI3K-A G02001876
#> 41: RV G02967907 GDC-0077 PI3K-A G02001876
#> 42: GR G02967907 GDC-0077 PI3K-A G02001876
#> 43: GR G02967907 GDC-0077 PI3K-A G02001876
#> 44: RV G02967907 GDC-0077 PI3K-A G02001876
#> 45: GR G02967907 GDC-0077 PI3K-A G02001876
#> 46: RV G02967907 GDC-0077 PI3K-A G02001876
#> 47: GR G02967907 GDC-0077 PI3K-A G02001876
#> 48: RV G02967907 GDC-0077 PI3K-A G02001876
#> 49: GR G02967907 GDC-0077 PI3K-A G02001876
#> 50: GR G02967907 GDC-0077 PI3K-A G02001876
#> 51: RV G02967907 GDC-0077 PI3K-A G02001876
#> 52: GR G02967907 GDC-0077 PI3K-A G02001876
#> 53: RV G02967907 GDC-0077 PI3K-A G02001876
#> 54: GR G02967907 GDC-0077 PI3K-A G02001876
#> 55: RV G02967907 GDC-0077 PI3K-A G02001876
#> 56: RV G02967907 GDC-0077 PI3K-A G02001876
#> 57: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 58: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 59: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 60: <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 61: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 62: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 63: <NA> G02967907 GDC-0077 PI3K-A <NA>
#> 64: GR G02967907 GDC-0077 PI3K-A G02001876
#> 65: GR G02967907 GDC-0077 PI3K-A G02001876
#> 66: GR G02967907 GDC-0077 PI3K-A G02001876
#> 67: RV G02967907 GDC-0077 PI3K-A G02001876
#> 68: RV G02967907 GDC-0077 PI3K-A G02001876
#> 69: RV G02967907 GDC-0077 PI3K-A G02001876
#> 70: GR G02967907 GDC-0077 PI3K-A G02001876
#> normalization_type i.Gnumber i.DrugName i.drug_moa i.Gnumber_2
#> i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid
#> 1: <NA> <NA> <NA> <NA> 168 CL129757
#> 2: <NA> <NA> <NA> <NA> 168 CL130742
#> 3: <NA> <NA> <NA> <NA> 168 CL131873
#> 4: <NA> <NA> <NA> <NA> 168 CL131903
#> 5: <NA> <NA> <NA> <NA> 168 CL130218
#> 6: <NA> <NA> <NA> <NA> 168 CL131438
#> 7: <NA> <NA> <NA> <NA> 168 CL131891
#> 8: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 9: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 10: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 11: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 12: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 13: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 14: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 15: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 16: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 17: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 18: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 19: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 20: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 21: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 22: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 23: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 24: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 25: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 26: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 27: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 28: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 29: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 30: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 31: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 32: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 33: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 34: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 35: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 36: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 37: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 38: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 39: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 40: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 41: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 42: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 43: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 44: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 45: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 46: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 47: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 48: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 49: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 50: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 51: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 52: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 53: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 54: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 55: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 56: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> 57: <NA> <NA> <NA> <NA> 168 CL129757
#> 58: <NA> <NA> <NA> <NA> 168 CL130742
#> 59: <NA> <NA> <NA> <NA> 168 CL131873
#> 60: <NA> <NA> <NA> <NA> 168 CL131903
#> 61: <NA> <NA> <NA> <NA> 168 CL130218
#> 62: <NA> <NA> <NA> <NA> 168 CL131438
#> 63: <NA> <NA> <NA> <NA> 168 CL131891
#> 64: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL129757
#> 65: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130218
#> 66: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL130742
#> 67: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131438
#> 68: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131873
#> 69: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131891
#> 70: Palbociclib CDK4|CDK6 vehicle vehicle 168 CL131903
#> i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid
#> i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: MCF-7 Breast MCF-7 unknown
#> 2: T-47D Breast T-47D unknown
#> 3: HCC1428 Breast HCC1428 unknown
#> 4: BT-483 Breast BT-483 unknown
#> 5: BT-474 Breast BT-474 unknown
#> 6: CAMA-1 Breast CAMA-1 unknown
#> 7: EFM-19 Breast EFM-19 unknown
#> 8: MCF-7 Breast MCF-7 unknown
#> 9: MCF-7 Breast MCF-7 unknown
#> 10: MCF-7 Breast MCF-7 unknown
#> 11: MCF-7 Breast MCF-7 unknown
#> 12: MCF-7 Breast MCF-7 unknown
#> 13: MCF-7 Breast MCF-7 unknown
#> 14: MCF-7 Breast MCF-7 unknown
#> 15: BT-474 Breast BT-474 unknown
#> 16: BT-474 Breast BT-474 unknown
#> 17: BT-474 Breast BT-474 unknown
#> 18: BT-474 Breast BT-474 unknown
#> 19: BT-474 Breast BT-474 unknown
#> 20: BT-474 Breast BT-474 unknown
#> 21: BT-474 Breast BT-474 unknown
#> 22: T-47D Breast T-47D unknown
#> 23: T-47D Breast T-47D unknown
#> 24: T-47D Breast T-47D unknown
#> 25: T-47D Breast T-47D unknown
#> 26: T-47D Breast T-47D unknown
#> 27: T-47D Breast T-47D unknown
#> 28: T-47D Breast T-47D unknown
#> 29: CAMA-1 Breast CAMA-1 unknown
#> 30: CAMA-1 Breast CAMA-1 unknown
#> 31: CAMA-1 Breast CAMA-1 unknown
#> 32: CAMA-1 Breast CAMA-1 unknown
#> 33: CAMA-1 Breast CAMA-1 unknown
#> 34: CAMA-1 Breast CAMA-1 unknown
#> 35: CAMA-1 Breast CAMA-1 unknown
#> 36: HCC1428 Breast HCC1428 unknown
#> 37: HCC1428 Breast HCC1428 unknown
#> 38: HCC1428 Breast HCC1428 unknown
#> 39: HCC1428 Breast HCC1428 unknown
#> 40: HCC1428 Breast HCC1428 unknown
#> 41: HCC1428 Breast HCC1428 unknown
#> 42: HCC1428 Breast HCC1428 unknown
#> 43: EFM-19 Breast EFM-19 unknown
#> 44: EFM-19 Breast EFM-19 unknown
#> 45: EFM-19 Breast EFM-19 unknown
#> 46: EFM-19 Breast EFM-19 unknown
#> 47: EFM-19 Breast EFM-19 unknown
#> 48: EFM-19 Breast EFM-19 unknown
#> 49: EFM-19 Breast EFM-19 unknown
#> 50: BT-483 Breast BT-483 unknown
#> 51: BT-483 Breast BT-483 unknown
#> 52: BT-483 Breast BT-483 unknown
#> 53: BT-483 Breast BT-483 unknown
#> 54: BT-483 Breast BT-483 unknown
#> 55: BT-483 Breast BT-483 unknown
#> 56: BT-483 Breast BT-483 unknown
#> 57: MCF-7 Breast MCF-7 unknown
#> 58: T-47D Breast T-47D unknown
#> 59: HCC1428 Breast HCC1428 unknown
#> 60: BT-483 Breast BT-483 unknown
#> 61: BT-474 Breast BT-474 unknown
#> 62: CAMA-1 Breast CAMA-1 unknown
#> 63: EFM-19 Breast EFM-19 unknown
#> 64: MCF-7 Breast MCF-7 unknown
#> 65: BT-474 Breast BT-474 unknown
#> 66: T-47D Breast T-47D unknown
#> 67: CAMA-1 Breast CAMA-1 unknown
#> 68: HCC1428 Breast HCC1428 unknown
#> 69: EFM-19 Breast EFM-19 unknown
#> 70: BT-483 Breast BT-483 unknown
#> i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 60
#> 3: 74
#> 4: 130
#> 5: 70
#> 6: 53
#> 7: 64
#> 8: 30
#> 9: 30
#> 10: 30
#> 11: 30
#> 12: 30
#> 13: 30
#> 14: 30
#> 15: 70
#> 16: 70
#> 17: 70
#> 18: 70
#> 19: 70
#> 20: 70
#> 21: 70
#> 22: 60
#> 23: 60
#> 24: 60
#> 25: 60
#> 26: 60
#> 27: 60
#> 28: 60
#> 29: 53
#> 30: 53
#> 31: 53
#> 32: 53
#> 33: 53
#> 34: 53
#> 35: 53
#> 36: 74
#> 37: 74
#> 38: 74
#> 39: 74
#> 40: 74
#> 41: 74
#> 42: 74
#> 43: 64
#> 44: 64
#> 45: 64
#> 46: 64
#> 47: 64
#> 48: 64
#> 49: 64
#> 50: 130
#> 51: 130
#> 52: 130
#> 53: 130
#> 54: 130
#> 55: 130
#> 56: 130
#> 57: 30
#> 58: 60
#> 59: 74
#> 60: 130
#> 61: 70
#> 62: 53
#> 63: 64
#> 64: 30
#> 65: 70
#> 66: 60
#> 67: 53
#> 68: 74
#> 69: 64
#> 70: 130
#> i.ReferenceDivisionTime
#>
#> $all_iso_points
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: G02001876_Palbociclib_CDK4|CDK6_168
#> 16: G02001876_Palbociclib_CDK4|CDK6_168
#> 17: G02001876_Palbociclib_CDK4|CDK6_168
#> 18: G02001876_Palbociclib_CDK4|CDK6_168
#> 19: G02967907_GDC-0077_PI3K-A_168
#> 20: G02967907_GDC-0077_PI3K-A_168
#> 21: G02967907_GDC-0077_PI3K-A_168
#> 22: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 23: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 24: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 25: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 26: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 27: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 28: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 16: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 17: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 18: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 19: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 20: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 21: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 22: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 23: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 24: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 25: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 26: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 27: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 28: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 16: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 17: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 18: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 19: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 20: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 21: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 22: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 23: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 24: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 25: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 26: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 27: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 28: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: MCF-7 30 Breast CL129757 MCF-7
#> 16: T-47D 60 Breast CL130742 T-47D
#> 17: HCC1428 74 Breast CL131873 HCC1428
#> 18: BT-483 130 Breast CL131903 BT-483
#> 19: BT-474 70 Breast CL130218 BT-474
#> 20: CAMA-1 53 Breast CL131438 CAMA-1
#> 21: EFM-19 64 Breast CL131891 EFM-19
#> 22: MCF-7 30 Breast CL129757 MCF-7
#> 23: BT-474 70 Breast CL130218 BT-474
#> 24: T-47D 60 Breast CL130742 T-47D
#> 25: CAMA-1 53 Breast CL131438 CAMA-1
#> 26: HCC1428 74 Breast CL131873 HCC1428
#> 27: EFM-19 64 Breast CL131891 EFM-19
#> 28: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type normalization_type i.Gnumber i.DrugName i.drug_moa
#> 1: <NA> single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 2: <NA> single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 3: <NA> single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 4: <NA> single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 5: <NA> single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 6: <NA> single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 7: <NA> single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 8: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 9: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 10: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 11: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 12: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 13: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 14: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 15: unknown single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 16: unknown single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 17: unknown single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 18: unknown single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 19: unknown single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 20: unknown single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 21: unknown single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 22: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 23: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 24: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 25: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 26: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 27: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 28: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> subtype data_type normalization_type i.Gnumber i.DrugName i.drug_moa
#> i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration
#> 1: <NA> <NA> <NA> <NA> <NA> 168
#> 2: <NA> <NA> <NA> <NA> <NA> 168
#> 3: <NA> <NA> <NA> <NA> <NA> 168
#> 4: <NA> <NA> <NA> <NA> <NA> 168
#> 5: <NA> <NA> <NA> <NA> <NA> 168
#> 6: <NA> <NA> <NA> <NA> <NA> 168
#> 7: <NA> <NA> <NA> <NA> <NA> 168
#> 8: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 9: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 10: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 11: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 12: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 13: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 14: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 15: <NA> <NA> <NA> <NA> <NA> 168
#> 16: <NA> <NA> <NA> <NA> <NA> 168
#> 17: <NA> <NA> <NA> <NA> <NA> 168
#> 18: <NA> <NA> <NA> <NA> <NA> 168
#> 19: <NA> <NA> <NA> <NA> <NA> 168
#> 20: <NA> <NA> <NA> <NA> <NA> 168
#> 21: <NA> <NA> <NA> <NA> <NA> 168
#> 22: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 23: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 24: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 25: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 26: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 27: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 28: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration
#> i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: CL129757 MCF-7 Breast MCF-7 unknown
#> 2: CL130742 T-47D Breast T-47D unknown
#> 3: CL131873 HCC1428 Breast HCC1428 unknown
#> 4: CL131903 BT-483 Breast BT-483 unknown
#> 5: CL130218 BT-474 Breast BT-474 unknown
#> 6: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 7: CL131891 EFM-19 Breast EFM-19 unknown
#> 8: CL129757 MCF-7 Breast MCF-7 unknown
#> 9: CL130218 BT-474 Breast BT-474 unknown
#> 10: CL130742 T-47D Breast T-47D unknown
#> 11: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 12: CL131873 HCC1428 Breast HCC1428 unknown
#> 13: CL131891 EFM-19 Breast EFM-19 unknown
#> 14: CL131903 BT-483 Breast BT-483 unknown
#> 15: CL129757 MCF-7 Breast MCF-7 unknown
#> 16: CL130742 T-47D Breast T-47D unknown
#> 17: CL131873 HCC1428 Breast HCC1428 unknown
#> 18: CL131903 BT-483 Breast BT-483 unknown
#> 19: CL130218 BT-474 Breast BT-474 unknown
#> 20: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 21: CL131891 EFM-19 Breast EFM-19 unknown
#> 22: CL129757 MCF-7 Breast MCF-7 unknown
#> 23: CL130218 BT-474 Breast BT-474 unknown
#> 24: CL130742 T-47D Breast T-47D unknown
#> 25: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 26: CL131873 HCC1428 Breast HCC1428 unknown
#> 27: CL131891 EFM-19 Breast EFM-19 unknown
#> 28: CL131903 BT-483 Breast BT-483 unknown
#> i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime x
#> 1: 30 NA
#> 2: 60 NA
#> 3: 74 NA
#> 4: 130 NA
#> 5: 70 NA
#> 6: 53 NA
#> 7: 64 NA
#> 8: 30 NA
#> 9: 70 NA
#> 10: 60 NA
#> 11: 53 NA
#> 12: 74 NA
#> 13: 64 NA
#> 14: 130 NA
#> 15: 30 NA
#> 16: 60 NA
#> 17: 74 NA
#> 18: 130 NA
#> 19: 70 NA
#> 20: 53 NA
#> 21: 64 NA
#> 22: 30 NA
#> 23: 70 NA
#> 24: 60 NA
#> 25: 53 NA
#> 26: 74 NA
#> 27: 64 NA
#> 28: 130 NA
#> i.ReferenceDivisionTime x
#>
#> $isobolograms
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: G02001876_Palbociclib_CDK4|CDK6_168
#> 16: G02001876_Palbociclib_CDK4|CDK6_168
#> 17: G02001876_Palbociclib_CDK4|CDK6_168
#> 18: G02001876_Palbociclib_CDK4|CDK6_168
#> 19: G02967907_GDC-0077_PI3K-A_168
#> 20: G02967907_GDC-0077_PI3K-A_168
#> 21: G02967907_GDC-0077_PI3K-A_168
#> 22: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 23: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 24: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 25: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 26: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 27: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 28: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 16: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 17: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 18: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 19: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 20: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 21: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 22: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 23: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 24: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 25: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 26: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 27: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 28: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 16: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 17: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 18: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 19: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 20: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 21: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 22: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 23: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 24: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 25: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 26: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 27: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 28: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: MCF-7 30 Breast CL129757 MCF-7
#> 16: T-47D 60 Breast CL130742 T-47D
#> 17: HCC1428 74 Breast CL131873 HCC1428
#> 18: BT-483 130 Breast CL131903 BT-483
#> 19: BT-474 70 Breast CL130218 BT-474
#> 20: CAMA-1 53 Breast CL131438 CAMA-1
#> 21: EFM-19 64 Breast CL131891 EFM-19
#> 22: MCF-7 30 Breast CL129757 MCF-7
#> 23: BT-474 70 Breast CL130218 BT-474
#> 24: T-47D 60 Breast CL130742 T-47D
#> 25: CAMA-1 53 Breast CL131438 CAMA-1
#> 26: HCC1428 74 Breast CL131873 HCC1428
#> 27: EFM-19 64 Breast CL131891 EFM-19
#> 28: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type normalization_type i.Gnumber i.DrugName i.drug_moa
#> 1: <NA> single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 2: <NA> single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 3: <NA> single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 4: <NA> single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 5: <NA> single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 6: <NA> single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 7: <NA> single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 8: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 9: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 10: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 11: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 12: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 13: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 14: <NA> matrix GR G02967907 GDC-0077 PI3K-A
#> 15: unknown single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 16: unknown single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 17: unknown single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 18: unknown single-agent <NA> G02001876 Palbociclib CDK4|CDK6
#> 19: unknown single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 20: unknown single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 21: unknown single-agent <NA> G02967907 GDC-0077 PI3K-A
#> 22: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 23: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 24: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 25: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 26: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 27: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> 28: unknown matrix RV G02967907 GDC-0077 PI3K-A
#> subtype data_type normalization_type i.Gnumber i.DrugName i.drug_moa
#> i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration
#> 1: <NA> <NA> <NA> <NA> <NA> 168
#> 2: <NA> <NA> <NA> <NA> <NA> 168
#> 3: <NA> <NA> <NA> <NA> <NA> 168
#> 4: <NA> <NA> <NA> <NA> <NA> 168
#> 5: <NA> <NA> <NA> <NA> <NA> 168
#> 6: <NA> <NA> <NA> <NA> <NA> 168
#> 7: <NA> <NA> <NA> <NA> <NA> 168
#> 8: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 9: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 10: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 11: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 12: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 13: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 14: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 15: <NA> <NA> <NA> <NA> <NA> 168
#> 16: <NA> <NA> <NA> <NA> <NA> 168
#> 17: <NA> <NA> <NA> <NA> <NA> 168
#> 18: <NA> <NA> <NA> <NA> <NA> 168
#> 19: <NA> <NA> <NA> <NA> <NA> 168
#> 20: <NA> <NA> <NA> <NA> <NA> 168
#> 21: <NA> <NA> <NA> <NA> <NA> 168
#> 22: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 23: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 24: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 25: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 26: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 27: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 28: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration
#> i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: CL129757 MCF-7 Breast MCF-7 unknown
#> 2: CL130742 T-47D Breast T-47D unknown
#> 3: CL131873 HCC1428 Breast HCC1428 unknown
#> 4: CL131903 BT-483 Breast BT-483 unknown
#> 5: CL130218 BT-474 Breast BT-474 unknown
#> 6: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 7: CL131891 EFM-19 Breast EFM-19 unknown
#> 8: CL129757 MCF-7 Breast MCF-7 unknown
#> 9: CL130218 BT-474 Breast BT-474 unknown
#> 10: CL130742 T-47D Breast T-47D unknown
#> 11: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 12: CL131873 HCC1428 Breast HCC1428 unknown
#> 13: CL131891 EFM-19 Breast EFM-19 unknown
#> 14: CL131903 BT-483 Breast BT-483 unknown
#> 15: CL129757 MCF-7 Breast MCF-7 unknown
#> 16: CL130742 T-47D Breast T-47D unknown
#> 17: CL131873 HCC1428 Breast HCC1428 unknown
#> 18: CL131903 BT-483 Breast BT-483 unknown
#> 19: CL130218 BT-474 Breast BT-474 unknown
#> 20: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 21: CL131891 EFM-19 Breast EFM-19 unknown
#> 22: CL129757 MCF-7 Breast MCF-7 unknown
#> 23: CL130218 BT-474 Breast BT-474 unknown
#> 24: CL130742 T-47D Breast T-47D unknown
#> 25: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 26: CL131873 HCC1428 Breast HCC1428 unknown
#> 27: CL131891 EFM-19 Breast EFM-19 unknown
#> 28: CL131903 BT-483 Breast BT-483 unknown
#> i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime x
#> 1: 30 NA
#> 2: 60 NA
#> 3: 74 NA
#> 4: 130 NA
#> 5: 70 NA
#> 6: 53 NA
#> 7: 64 NA
#> 8: 30 NA
#> 9: 70 NA
#> 10: 60 NA
#> 11: 53 NA
#> 12: 74 NA
#> 13: 64 NA
#> 14: 130 NA
#> 15: 30 NA
#> 16: 60 NA
#> 17: 74 NA
#> 18: 130 NA
#> 19: 70 NA
#> 20: 53 NA
#> 21: 64 NA
#> 22: 30 NA
#> 23: 70 NA
#> 24: 60 NA
#> 25: 53 NA
#> 26: 74 NA
#> 27: 64 NA
#> 28: 130 NA
#> i.ReferenceDivisionTime x
#>
#> $BlissScore
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: G02001876_Palbociclib_CDK4|CDK6_168
#> 16: G02001876_Palbociclib_CDK4|CDK6_168
#> 17: G02001876_Palbociclib_CDK4|CDK6_168
#> 18: G02001876_Palbociclib_CDK4|CDK6_168
#> 19: G02967907_GDC-0077_PI3K-A_168
#> 20: G02967907_GDC-0077_PI3K-A_168
#> 21: G02967907_GDC-0077_PI3K-A_168
#> 22: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 23: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 24: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 25: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 26: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 27: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 28: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 16: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 17: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 18: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 19: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 20: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 21: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 22: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 23: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 24: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 25: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 26: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 27: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 28: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 16: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 17: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 18: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 19: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 20: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 21: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 22: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 23: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 24: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 25: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 26: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 27: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 28: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: MCF-7 30 Breast CL129757 MCF-7
#> 16: T-47D 60 Breast CL130742 T-47D
#> 17: HCC1428 74 Breast CL131873 HCC1428
#> 18: BT-483 130 Breast CL131903 BT-483
#> 19: BT-474 70 Breast CL130218 BT-474
#> 20: CAMA-1 53 Breast CL131438 CAMA-1
#> 21: EFM-19 64 Breast CL131891 EFM-19
#> 22: MCF-7 30 Breast CL129757 MCF-7
#> 23: BT-474 70 Breast CL130218 BT-474
#> 24: T-47D 60 Breast CL130742 T-47D
#> 25: CAMA-1 53 Breast CL131438 CAMA-1
#> 26: HCC1428 74 Breast CL131873 HCC1428
#> 27: EFM-19 64 Breast CL131891 EFM-19
#> 28: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type normalization_type x i.Gnumber i.DrugName
#> 1: <NA> single-agent <NA> NA G02001876 Palbociclib
#> 2: <NA> single-agent <NA> NA G02001876 Palbociclib
#> 3: <NA> single-agent <NA> NA G02001876 Palbociclib
#> 4: <NA> single-agent <NA> NA G02001876 Palbociclib
#> 5: <NA> single-agent <NA> NA G02967907 GDC-0077
#> 6: <NA> single-agent <NA> NA G02967907 GDC-0077
#> 7: <NA> single-agent <NA> NA G02967907 GDC-0077
#> 8: <NA> matrix GR 0.25858907 G02967907 GDC-0077
#> 9: <NA> matrix GR 0.21241078 G02967907 GDC-0077
#> 10: <NA> matrix GR 0.30496602 G02967907 GDC-0077
#> 11: <NA> matrix GR -0.02970403 G02967907 GDC-0077
#> 12: <NA> matrix GR NaN G02967907 GDC-0077
#> 13: <NA> matrix GR NaN G02967907 GDC-0077
#> 14: <NA> matrix GR 0.45904274 G02967907 GDC-0077
#> 15: unknown single-agent <NA> NA G02001876 Palbociclib
#> 16: unknown single-agent <NA> NA G02001876 Palbociclib
#> 17: unknown single-agent <NA> NA G02001876 Palbociclib
#> 18: unknown single-agent <NA> NA G02001876 Palbociclib
#> 19: unknown single-agent <NA> NA G02967907 GDC-0077
#> 20: unknown single-agent <NA> NA G02967907 GDC-0077
#> 21: unknown single-agent <NA> NA G02967907 GDC-0077
#> 22: unknown matrix RV 0.04879045 G02967907 GDC-0077
#> 23: unknown matrix RV 0.15247017 G02967907 GDC-0077
#> 24: unknown matrix RV 0.03244561 G02967907 GDC-0077
#> 25: unknown matrix RV -0.04708806 G02967907 GDC-0077
#> 26: unknown matrix RV NaN G02967907 GDC-0077
#> 27: unknown matrix RV 0.03246174 G02967907 GDC-0077
#> 28: unknown matrix RV 0.01476427 G02967907 GDC-0077
#> subtype data_type normalization_type x i.Gnumber i.DrugName
#> i.drug_moa i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3
#> 1: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 2: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 3: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 4: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 5: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 6: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 7: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 8: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 9: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 10: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 11: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 12: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 13: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 14: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 15: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 16: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 17: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 18: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 19: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 20: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 21: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 22: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 23: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 24: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 25: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 26: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 27: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 28: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> i.drug_moa i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3
#> i.Duration i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: 168 CL129757 MCF-7 Breast MCF-7 unknown
#> 2: 168 CL130742 T-47D Breast T-47D unknown
#> 3: 168 CL131873 HCC1428 Breast HCC1428 unknown
#> 4: 168 CL131903 BT-483 Breast BT-483 unknown
#> 5: 168 CL130218 BT-474 Breast BT-474 unknown
#> 6: 168 CL131438 CAMA-1 Breast CAMA-1 unknown
#> 7: 168 CL131891 EFM-19 Breast EFM-19 unknown
#> 8: 168 CL129757 MCF-7 Breast MCF-7 unknown
#> 9: 168 CL130218 BT-474 Breast BT-474 unknown
#> 10: 168 CL130742 T-47D Breast T-47D unknown
#> 11: 168 CL131438 CAMA-1 Breast CAMA-1 unknown
#> 12: 168 CL131873 HCC1428 Breast HCC1428 unknown
#> 13: 168 CL131891 EFM-19 Breast EFM-19 unknown
#> 14: 168 CL131903 BT-483 Breast BT-483 unknown
#> 15: 168 CL129757 MCF-7 Breast MCF-7 unknown
#> 16: 168 CL130742 T-47D Breast T-47D unknown
#> 17: 168 CL131873 HCC1428 Breast HCC1428 unknown
#> 18: 168 CL131903 BT-483 Breast BT-483 unknown
#> 19: 168 CL130218 BT-474 Breast BT-474 unknown
#> 20: 168 CL131438 CAMA-1 Breast CAMA-1 unknown
#> 21: 168 CL131891 EFM-19 Breast EFM-19 unknown
#> 22: 168 CL129757 MCF-7 Breast MCF-7 unknown
#> 23: 168 CL130218 BT-474 Breast BT-474 unknown
#> 24: 168 CL130742 T-47D Breast T-47D unknown
#> 25: 168 CL131438 CAMA-1 Breast CAMA-1 unknown
#> 26: 168 CL131873 HCC1428 Breast HCC1428 unknown
#> 27: 168 CL131891 EFM-19 Breast EFM-19 unknown
#> 28: 168 CL131903 BT-483 Breast BT-483 unknown
#> i.Duration i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 60
#> 3: 74
#> 4: 130
#> 5: 70
#> 6: 53
#> 7: 64
#> 8: 30
#> 9: 70
#> 10: 60
#> 11: 53
#> 12: 74
#> 13: 64
#> 14: 130
#> 15: 30
#> 16: 60
#> 17: 74
#> 18: 130
#> 19: 70
#> 20: 53
#> 21: 64
#> 22: 30
#> 23: 70
#> 24: 60
#> 25: 53
#> 26: 74
#> 27: 64
#> 28: 130
#> i.ReferenceDivisionTime
#>
#> $HSAScore
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: G02001876_Palbociclib_CDK4|CDK6_168
#> 16: G02001876_Palbociclib_CDK4|CDK6_168
#> 17: G02001876_Palbociclib_CDK4|CDK6_168
#> 18: G02001876_Palbociclib_CDK4|CDK6_168
#> 19: G02967907_GDC-0077_PI3K-A_168
#> 20: G02967907_GDC-0077_PI3K-A_168
#> 21: G02967907_GDC-0077_PI3K-A_168
#> 22: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 23: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 24: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 25: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 26: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 27: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 28: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 16: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 17: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 18: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 19: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 20: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 21: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 22: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 23: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 24: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 25: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 26: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 27: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 28: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 16: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 17: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 18: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 19: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 20: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 21: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 22: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 23: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 24: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 25: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 26: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 27: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 28: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: MCF-7 30 Breast CL129757 MCF-7
#> 16: T-47D 60 Breast CL130742 T-47D
#> 17: HCC1428 74 Breast CL131873 HCC1428
#> 18: BT-483 130 Breast CL131903 BT-483
#> 19: BT-474 70 Breast CL130218 BT-474
#> 20: CAMA-1 53 Breast CL131438 CAMA-1
#> 21: EFM-19 64 Breast CL131891 EFM-19
#> 22: MCF-7 30 Breast CL129757 MCF-7
#> 23: BT-474 70 Breast CL130218 BT-474
#> 24: T-47D 60 Breast CL130742 T-47D
#> 25: CAMA-1 53 Breast CL131438 CAMA-1
#> 26: HCC1428 74 Breast CL131873 HCC1428
#> 27: EFM-19 64 Breast CL131891 EFM-19
#> 28: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type normalization_type x i.Gnumber i.DrugName
#> 1: <NA> single-agent <NA> NA G02001876 Palbociclib
#> 2: <NA> single-agent <NA> NA G02001876 Palbociclib
#> 3: <NA> single-agent <NA> NA G02001876 Palbociclib
#> 4: <NA> single-agent <NA> NA G02001876 Palbociclib
#> 5: <NA> single-agent <NA> NA G02967907 GDC-0077
#> 6: <NA> single-agent <NA> NA G02967907 GDC-0077
#> 7: <NA> single-agent <NA> NA G02967907 GDC-0077
#> 8: <NA> matrix GR 0.4841219683 G02967907 GDC-0077
#> 9: <NA> matrix GR 0.3772046188 G02967907 GDC-0077
#> 10: <NA> matrix GR 0.2921312256 G02967907 GDC-0077
#> 11: <NA> matrix GR -0.0007592983 G02967907 GDC-0077
#> 12: <NA> matrix GR NaN G02967907 GDC-0077
#> 13: <NA> matrix GR NaN G02967907 GDC-0077
#> 14: <NA> matrix GR 0.5922588391 G02967907 GDC-0077
#> 15: unknown single-agent <NA> NA G02001876 Palbociclib
#> 16: unknown single-agent <NA> NA G02001876 Palbociclib
#> 17: unknown single-agent <NA> NA G02001876 Palbociclib
#> 18: unknown single-agent <NA> NA G02001876 Palbociclib
#> 19: unknown single-agent <NA> NA G02967907 GDC-0077
#> 20: unknown single-agent <NA> NA G02967907 GDC-0077
#> 21: unknown single-agent <NA> NA G02967907 GDC-0077
#> 22: unknown matrix RV 0.2753005792 G02967907 GDC-0077
#> 23: unknown matrix RV 0.2417955856 G02967907 GDC-0077
#> 24: unknown matrix RV 0.1734790818 G02967907 GDC-0077
#> 25: unknown matrix RV -0.0002909946 G02967907 GDC-0077
#> 26: unknown matrix RV NaN G02967907 GDC-0077
#> 27: unknown matrix RV 0.1787512356 G02967907 GDC-0077
#> 28: unknown matrix RV 0.1366652981 G02967907 GDC-0077
#> subtype data_type normalization_type x i.Gnumber i.DrugName
#> i.drug_moa i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3
#> 1: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 2: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 3: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 4: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 5: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 6: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 7: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 8: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 9: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 10: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 11: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 12: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 13: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 14: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 15: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 16: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 17: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 18: CDK4|CDK6 <NA> <NA> <NA> <NA> <NA>
#> 19: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 20: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 21: PI3K-A <NA> <NA> <NA> <NA> <NA>
#> 22: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 23: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 24: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 25: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 26: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 27: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> 28: PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle vehicle
#> i.drug_moa i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3
#> i.Duration i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: 168 CL129757 MCF-7 Breast MCF-7 unknown
#> 2: 168 CL130742 T-47D Breast T-47D unknown
#> 3: 168 CL131873 HCC1428 Breast HCC1428 unknown
#> 4: 168 CL131903 BT-483 Breast BT-483 unknown
#> 5: 168 CL130218 BT-474 Breast BT-474 unknown
#> 6: 168 CL131438 CAMA-1 Breast CAMA-1 unknown
#> 7: 168 CL131891 EFM-19 Breast EFM-19 unknown
#> 8: 168 CL129757 MCF-7 Breast MCF-7 unknown
#> 9: 168 CL130218 BT-474 Breast BT-474 unknown
#> 10: 168 CL130742 T-47D Breast T-47D unknown
#> 11: 168 CL131438 CAMA-1 Breast CAMA-1 unknown
#> 12: 168 CL131873 HCC1428 Breast HCC1428 unknown
#> 13: 168 CL131891 EFM-19 Breast EFM-19 unknown
#> 14: 168 CL131903 BT-483 Breast BT-483 unknown
#> 15: 168 CL129757 MCF-7 Breast MCF-7 unknown
#> 16: 168 CL130742 T-47D Breast T-47D unknown
#> 17: 168 CL131873 HCC1428 Breast HCC1428 unknown
#> 18: 168 CL131903 BT-483 Breast BT-483 unknown
#> 19: 168 CL130218 BT-474 Breast BT-474 unknown
#> 20: 168 CL131438 CAMA-1 Breast CAMA-1 unknown
#> 21: 168 CL131891 EFM-19 Breast EFM-19 unknown
#> 22: 168 CL129757 MCF-7 Breast MCF-7 unknown
#> 23: 168 CL130218 BT-474 Breast BT-474 unknown
#> 24: 168 CL130742 T-47D Breast T-47D unknown
#> 25: 168 CL131438 CAMA-1 Breast CAMA-1 unknown
#> 26: 168 CL131873 HCC1428 Breast HCC1428 unknown
#> 27: 168 CL131891 EFM-19 Breast EFM-19 unknown
#> 28: 168 CL131903 BT-483 Breast BT-483 unknown
#> i.Duration i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 60
#> 3: 74
#> 4: 130
#> 5: 70
#> 6: 53
#> 7: 64
#> 8: 30
#> 9: 70
#> 10: 60
#> 11: 53
#> 12: 74
#> 13: 64
#> 14: 130
#> 15: 30
#> 16: 60
#> 17: 74
#> 18: 130
#> 19: 70
#> 20: 53
#> 21: 64
#> 22: 30
#> 23: 70
#> 24: 60
#> 25: 53
#> 26: 74
#> 27: 64
#> 28: 130
#> i.ReferenceDivisionTime
#>
#> $CIScore_50
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: G02001876_Palbociclib_CDK4|CDK6_168
#> 16: G02001876_Palbociclib_CDK4|CDK6_168
#> 17: G02001876_Palbociclib_CDK4|CDK6_168
#> 18: G02001876_Palbociclib_CDK4|CDK6_168
#> 19: G02967907_GDC-0077_PI3K-A_168
#> 20: G02967907_GDC-0077_PI3K-A_168
#> 21: G02967907_GDC-0077_PI3K-A_168
#> 22: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 23: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 24: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 25: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 26: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 27: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 28: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 16: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 17: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 18: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 19: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 20: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 21: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 22: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 23: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 24: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 25: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 26: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 27: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 28: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 16: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 17: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 18: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 19: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 20: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 21: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 22: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 23: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 24: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 25: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 26: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 27: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 28: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: MCF-7 30 Breast CL129757 MCF-7
#> 16: T-47D 60 Breast CL130742 T-47D
#> 17: HCC1428 74 Breast CL131873 HCC1428
#> 18: BT-483 130 Breast CL131903 BT-483
#> 19: BT-474 70 Breast CL130218 BT-474
#> 20: CAMA-1 53 Breast CL131438 CAMA-1
#> 21: EFM-19 64 Breast CL131891 EFM-19
#> 22: MCF-7 30 Breast CL129757 MCF-7
#> 23: BT-474 70 Breast CL130218 BT-474
#> 24: T-47D 60 Breast CL130742 T-47D
#> 25: CAMA-1 53 Breast CL131438 CAMA-1
#> 26: HCC1428 74 Breast CL131873 HCC1428
#> 27: EFM-19 64 Breast CL131891 EFM-19
#> 28: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type normalization_type x i.Gnumber i.DrugName i.drug_moa
#> 1: <NA> single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 2: <NA> single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 3: <NA> single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 4: <NA> single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 5: <NA> single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 6: <NA> single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 7: <NA> single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 8: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 9: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 10: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 11: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 12: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 13: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 14: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 15: unknown single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 16: unknown single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 17: unknown single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 18: unknown single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 19: unknown single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 20: unknown single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 21: unknown single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 22: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 23: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 24: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 25: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 26: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 27: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 28: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> subtype data_type normalization_type x i.Gnumber i.DrugName i.drug_moa
#> i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration
#> 1: <NA> <NA> <NA> <NA> <NA> 168
#> 2: <NA> <NA> <NA> <NA> <NA> 168
#> 3: <NA> <NA> <NA> <NA> <NA> 168
#> 4: <NA> <NA> <NA> <NA> <NA> 168
#> 5: <NA> <NA> <NA> <NA> <NA> 168
#> 6: <NA> <NA> <NA> <NA> <NA> 168
#> 7: <NA> <NA> <NA> <NA> <NA> 168
#> 8: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 9: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 10: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 11: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 12: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 13: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 14: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 15: <NA> <NA> <NA> <NA> <NA> 168
#> 16: <NA> <NA> <NA> <NA> <NA> 168
#> 17: <NA> <NA> <NA> <NA> <NA> 168
#> 18: <NA> <NA> <NA> <NA> <NA> 168
#> 19: <NA> <NA> <NA> <NA> <NA> 168
#> 20: <NA> <NA> <NA> <NA> <NA> 168
#> 21: <NA> <NA> <NA> <NA> <NA> 168
#> 22: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 23: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 24: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 25: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 26: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 27: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 28: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration
#> i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: CL129757 MCF-7 Breast MCF-7 unknown
#> 2: CL130742 T-47D Breast T-47D unknown
#> 3: CL131873 HCC1428 Breast HCC1428 unknown
#> 4: CL131903 BT-483 Breast BT-483 unknown
#> 5: CL130218 BT-474 Breast BT-474 unknown
#> 6: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 7: CL131891 EFM-19 Breast EFM-19 unknown
#> 8: CL129757 MCF-7 Breast MCF-7 unknown
#> 9: CL130218 BT-474 Breast BT-474 unknown
#> 10: CL130742 T-47D Breast T-47D unknown
#> 11: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 12: CL131873 HCC1428 Breast HCC1428 unknown
#> 13: CL131891 EFM-19 Breast EFM-19 unknown
#> 14: CL131903 BT-483 Breast BT-483 unknown
#> 15: CL129757 MCF-7 Breast MCF-7 unknown
#> 16: CL130742 T-47D Breast T-47D unknown
#> 17: CL131873 HCC1428 Breast HCC1428 unknown
#> 18: CL131903 BT-483 Breast BT-483 unknown
#> 19: CL130218 BT-474 Breast BT-474 unknown
#> 20: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 21: CL131891 EFM-19 Breast EFM-19 unknown
#> 22: CL129757 MCF-7 Breast MCF-7 unknown
#> 23: CL130218 BT-474 Breast BT-474 unknown
#> 24: CL130742 T-47D Breast T-47D unknown
#> 25: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 26: CL131873 HCC1428 Breast HCC1428 unknown
#> 27: CL131891 EFM-19 Breast EFM-19 unknown
#> 28: CL131903 BT-483 Breast BT-483 unknown
#> i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 60
#> 3: 74
#> 4: 130
#> 5: 70
#> 6: 53
#> 7: 64
#> 8: 30
#> 9: 70
#> 10: 60
#> 11: 53
#> 12: 74
#> 13: 64
#> 14: 130
#> 15: 30
#> 16: 60
#> 17: 74
#> 18: 130
#> 19: 70
#> 20: 53
#> 21: 64
#> 22: 30
#> 23: 70
#> 24: 60
#> 25: 53
#> 26: 74
#> 27: 64
#> 28: 130
#> i.ReferenceDivisionTime
#>
#> $CIScore_80
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: G02001876_Palbociclib_CDK4|CDK6_168
#> 16: G02001876_Palbociclib_CDK4|CDK6_168
#> 17: G02001876_Palbociclib_CDK4|CDK6_168
#> 18: G02001876_Palbociclib_CDK4|CDK6_168
#> 19: G02967907_GDC-0077_PI3K-A_168
#> 20: G02967907_GDC-0077_PI3K-A_168
#> 21: G02967907_GDC-0077_PI3K-A_168
#> 22: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 23: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 24: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 25: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 26: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 27: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 28: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 16: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 17: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 18: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 19: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 20: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 21: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 22: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 23: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 24: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 25: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 26: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 27: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 28: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 16: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 17: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 18: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 19: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 20: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 21: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 22: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 23: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 24: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 25: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 26: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 27: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 28: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: MCF-7 30 Breast CL129757 MCF-7
#> 16: T-47D 60 Breast CL130742 T-47D
#> 17: HCC1428 74 Breast CL131873 HCC1428
#> 18: BT-483 130 Breast CL131903 BT-483
#> 19: BT-474 70 Breast CL130218 BT-474
#> 20: CAMA-1 53 Breast CL131438 CAMA-1
#> 21: EFM-19 64 Breast CL131891 EFM-19
#> 22: MCF-7 30 Breast CL129757 MCF-7
#> 23: BT-474 70 Breast CL130218 BT-474
#> 24: T-47D 60 Breast CL130742 T-47D
#> 25: CAMA-1 53 Breast CL131438 CAMA-1
#> 26: HCC1428 74 Breast CL131873 HCC1428
#> 27: EFM-19 64 Breast CL131891 EFM-19
#> 28: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type normalization_type x i.Gnumber i.DrugName i.drug_moa
#> 1: <NA> single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 2: <NA> single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 3: <NA> single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 4: <NA> single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 5: <NA> single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 6: <NA> single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 7: <NA> single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 8: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 9: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 10: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 11: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 12: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 13: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 14: <NA> matrix GR NA G02967907 GDC-0077 PI3K-A
#> 15: unknown single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 16: unknown single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 17: unknown single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 18: unknown single-agent <NA> NA G02001876 Palbociclib CDK4|CDK6
#> 19: unknown single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 20: unknown single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 21: unknown single-agent <NA> NA G02967907 GDC-0077 PI3K-A
#> 22: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 23: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 24: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 25: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 26: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 27: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> 28: unknown matrix RV NA G02967907 GDC-0077 PI3K-A
#> subtype data_type normalization_type x i.Gnumber i.DrugName i.drug_moa
#> i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration
#> 1: <NA> <NA> <NA> <NA> <NA> 168
#> 2: <NA> <NA> <NA> <NA> <NA> 168
#> 3: <NA> <NA> <NA> <NA> <NA> 168
#> 4: <NA> <NA> <NA> <NA> <NA> 168
#> 5: <NA> <NA> <NA> <NA> <NA> 168
#> 6: <NA> <NA> <NA> <NA> <NA> 168
#> 7: <NA> <NA> <NA> <NA> <NA> 168
#> 8: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 9: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 10: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 11: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 12: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 13: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 14: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 15: <NA> <NA> <NA> <NA> <NA> 168
#> 16: <NA> <NA> <NA> <NA> <NA> 168
#> 17: <NA> <NA> <NA> <NA> <NA> 168
#> 18: <NA> <NA> <NA> <NA> <NA> 168
#> 19: <NA> <NA> <NA> <NA> <NA> 168
#> 20: <NA> <NA> <NA> <NA> <NA> 168
#> 21: <NA> <NA> <NA> <NA> <NA> 168
#> 22: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 23: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 24: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 25: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 26: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 27: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> 28: G02001876 Palbociclib CDK4|CDK6 vehicle vehicle 168
#> i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration
#> i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: CL129757 MCF-7 Breast MCF-7 unknown
#> 2: CL130742 T-47D Breast T-47D unknown
#> 3: CL131873 HCC1428 Breast HCC1428 unknown
#> 4: CL131903 BT-483 Breast BT-483 unknown
#> 5: CL130218 BT-474 Breast BT-474 unknown
#> 6: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 7: CL131891 EFM-19 Breast EFM-19 unknown
#> 8: CL129757 MCF-7 Breast MCF-7 unknown
#> 9: CL130218 BT-474 Breast BT-474 unknown
#> 10: CL130742 T-47D Breast T-47D unknown
#> 11: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 12: CL131873 HCC1428 Breast HCC1428 unknown
#> 13: CL131891 EFM-19 Breast EFM-19 unknown
#> 14: CL131903 BT-483 Breast BT-483 unknown
#> 15: CL129757 MCF-7 Breast MCF-7 unknown
#> 16: CL130742 T-47D Breast T-47D unknown
#> 17: CL131873 HCC1428 Breast HCC1428 unknown
#> 18: CL131903 BT-483 Breast BT-483 unknown
#> 19: CL130218 BT-474 Breast BT-474 unknown
#> 20: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 21: CL131891 EFM-19 Breast EFM-19 unknown
#> 22: CL129757 MCF-7 Breast MCF-7 unknown
#> 23: CL130218 BT-474 Breast BT-474 unknown
#> 24: CL130742 T-47D Breast T-47D unknown
#> 25: CL131438 CAMA-1 Breast CAMA-1 unknown
#> 26: CL131873 HCC1428 Breast HCC1428 unknown
#> 27: CL131891 EFM-19 Breast EFM-19 unknown
#> 28: CL131903 BT-483 Breast BT-483 unknown
#> i.clid i.CellLineName i.Tissue i.parental_identifier i.subtype
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 60
#> 3: 74
#> 4: 130
#> 5: 70
#> 6: 53
#> 7: 64
#> 8: 30
#> 9: 70
#> 10: 60
#> 11: 53
#> 12: 74
#> 13: 64
#> 14: 130
#> 15: 30
#> 16: 60
#> 17: 74
#> 18: 130
#> 19: 70
#> 20: 53
#> 21: 64
#> 22: 30
#> 23: 70
#> 24: 60
#> 25: 53
#> 26: 74
#> 27: 64
#> 28: 130
#> i.ReferenceDivisionTime
#>
#> $Metrics
#> treatmentid
#> 1: <NA>
#> 2: <NA>
#> 3: <NA>
#> 4: <NA>
#> 5: <NA>
#> 6: <NA>
#> 7: <NA>
#> 8: <NA>
#> 9: <NA>
#> 10: <NA>
#> 11: <NA>
#> 12: <NA>
#> 13: <NA>
#> 14: <NA>
#> 15: <NA>
#> 16: <NA>
#> 17: <NA>
#> 18: <NA>
#> 19: <NA>
#> 20: <NA>
#> 21: <NA>
#> 22: <NA>
#> 23: <NA>
#> 24: <NA>
#> 25: <NA>
#> 26: <NA>
#> 27: <NA>
#> 28: <NA>
#> 29: <NA>
#> 30: <NA>
#> 31: <NA>
#> 32: <NA>
#> 33: <NA>
#> 34: <NA>
#> 35: <NA>
#> 36: <NA>
#> 37: <NA>
#> 38: <NA>
#> 39: <NA>
#> 40: <NA>
#> 41: <NA>
#> 42: <NA>
#> 43: <NA>
#> 44: <NA>
#> 45: <NA>
#> 46: <NA>
#> 47: <NA>
#> 48: <NA>
#> 49: <NA>
#> 50: G02001876_Palbociclib_CDK4|CDK6_168
#> 51: G02001876_Palbociclib_CDK4|CDK6_168
#> 52: G02001876_Palbociclib_CDK4|CDK6_168
#> 53: G02001876_Palbociclib_CDK4|CDK6_168
#> 54: G02001876_Palbociclib_CDK4|CDK6_168
#> 55: G02001876_Palbociclib_CDK4|CDK6_168
#> 56: G02001876_Palbociclib_CDK4|CDK6_168
#> 57: G02967907_GDC-0077_PI3K-A_168
#> 58: G02967907_GDC-0077_PI3K-A_168
#> 59: G02967907_GDC-0077_PI3K-A_168
#> 60: G02967907_GDC-0077_PI3K-A_168
#> 61: G02967907_GDC-0077_PI3K-A_168
#> 62: G02967907_GDC-0077_PI3K-A_168
#> 63: G02967907_GDC-0077_PI3K-A_168
#> 64: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 65: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 66: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 67: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 68: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 69: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> 70: G02967907_GDC-0077_PI3K-A_G02001876_Palbociclib_CDK4|CDK6_vehicle_vehicle_168
#> treatmentid
#> sampleid DrugName DrugName_2
#> 1: <NA> <NA> <NA>
#> 2: <NA> <NA> <NA>
#> 3: <NA> <NA> <NA>
#> 4: <NA> <NA> <NA>
#> 5: <NA> <NA> <NA>
#> 6: <NA> <NA> <NA>
#> 7: <NA> <NA> <NA>
#> 8: <NA> <NA> <NA>
#> 9: <NA> <NA> <NA>
#> 10: <NA> <NA> <NA>
#> 11: <NA> <NA> <NA>
#> 12: <NA> <NA> <NA>
#> 13: <NA> <NA> <NA>
#> 14: <NA> <NA> <NA>
#> 15: <NA> <NA> <NA>
#> 16: <NA> <NA> <NA>
#> 17: <NA> <NA> <NA>
#> 18: <NA> <NA> <NA>
#> 19: <NA> <NA> <NA>
#> 20: <NA> <NA> <NA>
#> 21: <NA> <NA> <NA>
#> 22: <NA> <NA> <NA>
#> 23: <NA> <NA> <NA>
#> 24: <NA> <NA> <NA>
#> 25: <NA> <NA> <NA>
#> 26: <NA> <NA> <NA>
#> 27: <NA> <NA> <NA>
#> 28: <NA> <NA> <NA>
#> 29: <NA> <NA> <NA>
#> 30: <NA> <NA> <NA>
#> 31: <NA> <NA> <NA>
#> 32: <NA> <NA> <NA>
#> 33: <NA> <NA> <NA>
#> 34: <NA> <NA> <NA>
#> 35: <NA> <NA> <NA>
#> 36: <NA> <NA> <NA>
#> 37: <NA> <NA> <NA>
#> 38: <NA> <NA> <NA>
#> 39: <NA> <NA> <NA>
#> 40: <NA> <NA> <NA>
#> 41: <NA> <NA> <NA>
#> 42: <NA> <NA> <NA>
#> 43: <NA> <NA> <NA>
#> 44: <NA> <NA> <NA>
#> 45: <NA> <NA> <NA>
#> 46: <NA> <NA> <NA>
#> 47: <NA> <NA> <NA>
#> 48: <NA> <NA> <NA>
#> 49: <NA> <NA> <NA>
#> 50: CL129757_MCF-7_Breast_MCF-7_unknown_30 Palbociclib <NA>
#> 51: CL130218_BT-474_Breast_BT-474_unknown_70 Palbociclib <NA>
#> 52: CL130742_T-47D_Breast_T-47D_unknown_60 Palbociclib <NA>
#> 53: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 Palbociclib <NA>
#> 54: CL131873_HCC1428_Breast_HCC1428_unknown_74 Palbociclib <NA>
#> 55: CL131891_EFM-19_Breast_EFM-19_unknown_64 Palbociclib <NA>
#> 56: CL131903_BT-483_Breast_BT-483_unknown_130 Palbociclib <NA>
#> 57: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 <NA>
#> 58: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 <NA>
#> 59: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 <NA>
#> 60: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 <NA>
#> 61: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 <NA>
#> 62: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 <NA>
#> 63: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 <NA>
#> 64: CL129757_MCF-7_Breast_MCF-7_unknown_30 GDC-0077 Palbociclib
#> 65: CL130218_BT-474_Breast_BT-474_unknown_70 GDC-0077 Palbociclib
#> 66: CL130742_T-47D_Breast_T-47D_unknown_60 GDC-0077 Palbociclib
#> 67: CL131438_CAMA-1_Breast_CAMA-1_unknown_53 GDC-0077 Palbociclib
#> 68: CL131873_HCC1428_Breast_HCC1428_unknown_74 GDC-0077 Palbociclib
#> 69: CL131891_EFM-19_Breast_EFM-19_unknown_64 GDC-0077 Palbociclib
#> 70: CL131903_BT-483_Breast_BT-483_unknown_130 GDC-0077 Palbociclib
#> sampleid DrugName DrugName_2
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> 1: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 15: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 16: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 17: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 18: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 19: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 20: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 21: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 22: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 23: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 24: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 25: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 26: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 27: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 28: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 29: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 30: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 31: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 32: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 33: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 34: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 35: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 36: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 37: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 38: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 39: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 40: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 41: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 42: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 43: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 44: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 45: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 46: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 47: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 48: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 49: <NA> NA <NA> <NA> <NA> <NA> <NA>
#> 50: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 51: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 52: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 53: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 54: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 55: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 56: <NA> 168 G02001876 <NA> CDK4|CDK6 <NA> <NA>
#> 57: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 58: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 59: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 60: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 61: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 62: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 63: <NA> 168 G02967907 <NA> PI3K-A <NA> <NA>
#> 64: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 65: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 66: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 67: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 68: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 69: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> 70: vehicle 168 G02967907 G02001876 PI3K-A CDK4|CDK6 vehicle
#> DrugName_3 Duration Gnumber Gnumber_2 drug_moa drug_moa_2 drug_moa_3
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> 1: <NA> NA <NA> <NA> <NA>
#> 2: <NA> NA <NA> <NA> <NA>
#> 3: <NA> NA <NA> <NA> <NA>
#> 4: <NA> NA <NA> <NA> <NA>
#> 5: <NA> NA <NA> <NA> <NA>
#> 6: <NA> NA <NA> <NA> <NA>
#> 7: <NA> NA <NA> <NA> <NA>
#> 8: <NA> NA <NA> <NA> <NA>
#> 9: <NA> NA <NA> <NA> <NA>
#> 10: <NA> NA <NA> <NA> <NA>
#> 11: <NA> NA <NA> <NA> <NA>
#> 12: <NA> NA <NA> <NA> <NA>
#> 13: <NA> NA <NA> <NA> <NA>
#> 14: <NA> NA <NA> <NA> <NA>
#> 15: <NA> NA <NA> <NA> <NA>
#> 16: <NA> NA <NA> <NA> <NA>
#> 17: <NA> NA <NA> <NA> <NA>
#> 18: <NA> NA <NA> <NA> <NA>
#> 19: <NA> NA <NA> <NA> <NA>
#> 20: <NA> NA <NA> <NA> <NA>
#> 21: <NA> NA <NA> <NA> <NA>
#> 22: <NA> NA <NA> <NA> <NA>
#> 23: <NA> NA <NA> <NA> <NA>
#> 24: <NA> NA <NA> <NA> <NA>
#> 25: <NA> NA <NA> <NA> <NA>
#> 26: <NA> NA <NA> <NA> <NA>
#> 27: <NA> NA <NA> <NA> <NA>
#> 28: <NA> NA <NA> <NA> <NA>
#> 29: <NA> NA <NA> <NA> <NA>
#> 30: <NA> NA <NA> <NA> <NA>
#> 31: <NA> NA <NA> <NA> <NA>
#> 32: <NA> NA <NA> <NA> <NA>
#> 33: <NA> NA <NA> <NA> <NA>
#> 34: <NA> NA <NA> <NA> <NA>
#> 35: <NA> NA <NA> <NA> <NA>
#> 36: <NA> NA <NA> <NA> <NA>
#> 37: <NA> NA <NA> <NA> <NA>
#> 38: <NA> NA <NA> <NA> <NA>
#> 39: <NA> NA <NA> <NA> <NA>
#> 40: <NA> NA <NA> <NA> <NA>
#> 41: <NA> NA <NA> <NA> <NA>
#> 42: <NA> NA <NA> <NA> <NA>
#> 43: <NA> NA <NA> <NA> <NA>
#> 44: <NA> NA <NA> <NA> <NA>
#> 45: <NA> NA <NA> <NA> <NA>
#> 46: <NA> NA <NA> <NA> <NA>
#> 47: <NA> NA <NA> <NA> <NA>
#> 48: <NA> NA <NA> <NA> <NA>
#> 49: <NA> NA <NA> <NA> <NA>
#> 50: MCF-7 30 Breast CL129757 MCF-7
#> 51: BT-474 70 Breast CL130218 BT-474
#> 52: T-47D 60 Breast CL130742 T-47D
#> 53: CAMA-1 53 Breast CL131438 CAMA-1
#> 54: HCC1428 74 Breast CL131873 HCC1428
#> 55: EFM-19 64 Breast CL131891 EFM-19
#> 56: BT-483 130 Breast CL131903 BT-483
#> 57: MCF-7 30 Breast CL129757 MCF-7
#> 58: BT-474 70 Breast CL130218 BT-474
#> 59: T-47D 60 Breast CL130742 T-47D
#> 60: CAMA-1 53 Breast CL131438 CAMA-1
#> 61: HCC1428 74 Breast CL131873 HCC1428
#> 62: EFM-19 64 Breast CL131891 EFM-19
#> 63: BT-483 130 Breast CL131903 BT-483
#> 64: MCF-7 30 Breast CL129757 MCF-7
#> 65: BT-474 70 Breast CL130218 BT-474
#> 66: T-47D 60 Breast CL130742 T-47D
#> 67: CAMA-1 53 Breast CL131438 CAMA-1
#> 68: HCC1428 74 Breast CL131873 HCC1428
#> 69: EFM-19 64 Breast CL131891 EFM-19
#> 70: BT-483 130 Breast CL131903 BT-483
#> CellLineName ReferenceDivisionTime Tissue clid parental_identifier
#> subtype data_type x_mean x_AOC x_AOC_range xc50
#> 1: <NA> single-agent 0.47661687 0.5233831 0.56857238 0.076498284
#> 2: <NA> single-agent 0.64380295 0.3561970 0.38288863 0.261198900
#> 3: <NA> single-agent 0.57974076 0.4202592 0.45608273 0.108022103
#> 4: <NA> single-agent 0.48880849 0.5111915 0.56200060 0.066290653
#> 5: <NA> single-agent 0.64585361 0.3541464 0.37706874 0.267817226
#> 6: <NA> single-agent 0.48212127 0.5178787 0.56398247 0.062941090
#> 7: <NA> single-agent 0.78688273 0.2131173 0.22911329 Inf
#> 8: <NA> single-agent 0.45076576 0.5492342 0.60135400 0.049111274
#> 9: <NA> single-agent 0.33941302 0.6605870 0.71398596 0.021133624
#> 10: <NA> single-agent 0.29130840 0.7086916 0.79538448 0.010875091
#> 11: <NA> single-agent 0.84727329 0.1527267 0.12683393 3.545565857
#> 12: <NA> single-agent 0.91973750 0.0802625 0.08026250 Inf
#> 13: <NA> single-agent 0.21628373 0.7837163 0.85346767 0.006243486
#> 14: <NA> single-agent 0.87118385 0.1288162 0.13612180 Inf
#> 15: <NA> matrix 0.01494479 0.9850552 1.02488491 -Inf
#> 16: <NA> matrix 0.03796714 0.9620329 0.98613007 -Inf
#> 17: <NA> matrix 0.13517167 0.8648283 0.88578895 -Inf
#> 18: <NA> matrix 0.13823983 0.8617602 0.87522661 -Inf
#> 19: <NA> matrix 0.45423175 0.5457683 0.58991097 0.061607661
#> 20: <NA> matrix -0.03265723 1.0326572 1.05526147 -Inf
#> 21: <NA> matrix -0.03263386 1.0326339 1.04525513 -Inf
#> 22: <NA> matrix 0.20932679 0.7906732 0.79697018 -Inf
#> 23: <NA> matrix 0.22814219 0.7718578 0.79066646 0.000842331
#> 24: <NA> matrix 0.34515403 0.6548460 0.69809969 0.044903280
#> 25: <NA> matrix -0.13240746 1.1324075 1.14330533 0.001242206
#> 26: <NA> matrix -0.10497778 1.1049778 1.10497778 -Inf
#> 27: <NA> matrix 0.11278573 0.8872143 0.90073419 -Inf
#> 28: <NA> matrix 0.11605278 0.8839472 0.88394722 -Inf
#> 29: <NA> matrix 0.35517666 0.6448233 0.72115254 0.031637592
#> 30: <NA> matrix 0.10474573 0.8952543 0.88507435 -Inf
#> 31: <NA> matrix 0.15225744 0.8477426 0.84451382 -Inf
#> 32: <NA> matrix 0.37810472 0.6218953 0.65030372 0.095437600
#> 33: <NA> matrix 0.40353815 0.5964618 0.62300306 0.084399349
#> 34: <NA> matrix 0.64910208 0.3508979 0.37633685 0.137228742
#> 35: <NA> matrix 0.48657778 0.5134222 0.51342222 -Inf
#> 36: <NA> matrix 0.53476667 0.4652333 0.46523333 Inf
#> 37: <NA> matrix 0.54210340 0.4578966 0.47669483 0.181806845
#> 38: <NA> matrix 0.55853753 0.4414625 0.44856567 0.302506072
#> 39: <NA> matrix 0.79127184 0.2087282 0.22324976 Inf
#> 40: <NA> matrix -0.34800075 1.3480008 1.35415087 -Inf
#> 41: <NA> matrix -0.21733333 1.2173333 1.21733333 -Inf
#> 42: <NA> matrix 0.07130278 0.9286972 0.92869722 -Inf
#> 43: <NA> matrix 0.11418508 0.8858149 0.91441513 -Inf
#> 44: <NA> matrix 0.16100779 0.8389922 0.91740319 0.012174469
#> 45: <NA> matrix -0.44261430 1.4426143 1.45515816 -Inf
#> 46: <NA> matrix -0.02539354 1.0253935 1.03673242 -Inf
#> 47: <NA> matrix 0.44788990 0.5521101 0.61012909 0.080082403
#> 48: <NA> matrix 0.51388976 0.4861102 0.50085455 0.046695147
#> 49: <NA> matrix 0.68834175 0.3116582 0.31228854 5.957526879
#> 50: unknown single-agent 0.47745137 0.5225486 0.55925164 0.110013317
#> 51: unknown single-agent 0.59168866 0.4083113 0.43380824 0.209120219
#> 52: unknown single-agent 0.54787038 0.4521296 0.48768396 0.116434314
#> 53: unknown single-agent 0.46893005 0.5310700 0.57869804 0.080602006
#> 54: unknown single-agent 0.66002312 0.3399769 0.35126094 0.460229801
#> 55: unknown single-agent 0.39884291 0.6011571 0.64874826 0.058976344
#> 56: unknown single-agent 0.34415070 0.6558493 0.70431757 0.105350274
#> 57: unknown single-agent 0.46875108 0.5312489 0.57775771 0.072352988
#> 58: unknown single-agent 0.10682978 0.8931702 0.95828951 0.016818913
#> 59: unknown single-agent 0.13542595 0.8645740 0.97099561 0.011763404
#> 60: unknown single-agent 0.87940512 0.1205949 0.09348317 5.139988166
#> 61: unknown single-agent 0.93637750 0.0636225 0.06362250 Inf
#> 62: unknown single-agent -0.07370905 1.0737091 1.18178452 0.006266606
#> 63: unknown single-agent 0.54092693 0.4590731 0.48826908 0.154597026
#> 64: unknown matrix 0.45973475 0.5402652 0.58005802 0.085938497
#> 65: unknown matrix 0.48519279 0.5148072 0.55380839 0.068718499
#> 66: unknown matrix 0.45718842 0.5428116 0.60935278 0.038810532
#> 67: unknown matrix 0.64957560 0.3504244 0.37597258 0.134098771
#> 68: unknown matrix 0.80109322 0.1989068 0.21003274 Inf
#> 69: unknown matrix 0.34777257 0.6522274 0.71034477 0.015650847
#> 70: unknown matrix 0.84133322 0.1586668 0.17932401 Inf
#> subtype data_type x_mean x_AOC x_AOC_range xc50
#> x_max ec50 x_inf x_0 h r2
#> 1: 0.1070500 6.354470e-02 0.086842045 1.00000000 1.0283168 0.9853800
#> 2: 0.2817500 9.897928e-02 0.320803238 1.00000000 1.0574543 0.9465590
#> 3: 0.2071250 8.784832e-02 0.219332586 1.00000000 2.7932767 0.9787945
#> 4: 0.1116250 5.911087e-02 0.123113102 1.00000000 2.4657832 0.9946671
#> 5: 0.2283000 1.362605e-01 0.275771259 1.00000000 1.1867664 0.9616801
#> 6: 0.1482250 4.029515e-02 0.165924419 1.00000000 0.9041923 0.9740112
#> 7: 0.5109750 1.124307e-01 0.582564142 1.00000000 2.5664444 0.9371648
#> 8: 0.1280000 3.573042e-02 0.135724609 1.00000000 0.9956354 0.9894700
#> 9: 0.0614500 1.842594e-02 0.048440035 1.00000000 0.7432213 0.9794880
#> 10: 0.0853250 9.658531e-03 0.097346337 1.00000000 1.8252137 0.9991625
#> 11: 0.2725250 3.270707e+00 0.040244433 1.00000000 1.0399258 0.8268608
#> 12: 0.8443750 0.000000e+00 0.919737500 0.91973750 0.0001000 0.0000000
#> 13: 0.0590750 5.649176e-03 0.055153325 1.00000000 1.1684452 0.9980626
#> 14: 0.6934000 1.637905e-01 0.725077429 1.00000000 1.1441480 0.8073673
#> 15: -0.1926500 2.016624e-02 -0.186867125 0.46578576 0.8394078 0.9955710
#> 16: -0.1792000 2.997876e-02 -0.209936698 0.45343716 0.5000027 0.9955964
#> 17: 0.0576500 8.125450e-03 0.057136525 0.40407827 0.7984411 0.9966058
#> 18: 0.0605750 7.433233e-03 0.054275151 0.38221268 0.5189088 0.9956945
#> 19: 0.1175250 5.663045e-02 0.131815892 0.91306298 1.3653578 0.9942492
#> 20: -0.4279500 1.643549e-01 -0.598266131 0.47985839 0.4535424 0.9391460
#> 21: -0.1074500 9.209460e-04 -0.096483113 0.34983716 0.4564793 0.7968090
#> 22: 0.1747000 4.140420e-04 0.179849683 0.44925724 0.4514748 0.8063646
#> 23: 0.0664250 4.254565e-03 0.000000000 0.80112921 0.3130875 0.9130486
#> 24: -0.1668375 7.276978e-02 -0.203321954 1.02167571 0.6188378 0.9066409
#> 25: -0.2162500 1.259659e-03 -0.143348114 1.10000000 4.9995937 0.7197596
#> 26: -0.1168250 0.000000e+00 -0.104977778 -0.10497778 0.0001000 0.0000000
#> 27: 0.0814750 1.044352e-03 0.086001850 0.49141491 0.9357183 0.9848189
#> 28: 0.1117250 0.000000e+00 0.116052778 0.11605278 0.0001000 0.0000000
#> 29: -0.0447875 2.945750e-02 -0.006504737 1.05705264 1.3323460 0.9171855
#> 30: -0.1108000 3.894799e+01 -0.935209440 0.14076971 0.8989277 0.9289353
#> 31: 0.0751500 9.157460e+00 0.000000000 0.16876993 0.8650140 0.9063180
#> 32: -0.0073250 1.084577e-01 0.028445271 0.74878673 5.0000000 0.9716583
#> 33: 0.1071250 9.376378e-02 0.120007413 0.72454073 5.0000000 0.9742342
#> 34: 0.1675375 1.116383e-01 0.326641536 0.98652339 5.0000000 0.8339422
#> 35: 0.4968000 0.000000e+00 0.486577778 0.48657778 0.0001000 0.0000000
#> 36: 0.5532750 0.000000e+00 0.534766667 0.53476667 0.0001000 0.0000000
#> 37: 0.2063250 1.397469e-01 0.204739815 0.86223893 0.7770357 0.9897505
#> 38: 0.1294000 3.479449e-01 0.119339590 0.83898727 0.8285188 0.9768379
#> 39: 0.5363375 1.146844e-01 0.602000943 0.98693523 5.0000000 0.8059504
#> 40: -0.3596250 1.524158e-04 -0.367156664 0.02191557 0.5621097 0.7496845
#> 41: -0.3941750 0.000000e+00 -0.217333333 -0.21733333 0.0001000 0.0000000
#> 42: 0.0674000 0.000000e+00 0.071302778 0.07130278 0.0001000 0.0000000
#> 43: 0.0591250 4.897815e-03 0.063738380 0.40931425 1.5965101 0.9980308
#> 44: -0.2519250 1.507756e-02 -0.210212171 1.10000000 0.7885011 0.8253181
#> 45: -0.5526500 5.740336e-04 -0.997177204 0.60064678 0.1203500 0.7182698
#> 46: -0.5912500 4.791737e-01 -0.706905623 0.38455547 0.5290236 0.9549554
#> 47: -0.2187000 7.917282e-02 -0.085572487 1.10000000 2.1307546 0.9363687
#> 48: 0.4689000 3.728209e-03 0.474132762 0.73429319 0.8717748 0.9290431
#> 49: 0.4483000 8.076935e+00 0.108902490 0.85072461 0.3579860 0.9623348
#> 50: -0.0170250 1.161741e-01 -0.031174681 1.00000000 1.1100114 0.9880388
#> 51: 0.1142750 1.360264e-01 0.165715558 1.00000000 0.9361851 0.9555750
#> 52: 0.1114250 1.033672e-01 0.130531849 1.00000000 2.5415386 0.9815621
#> 53: 0.0071000 7.791439e-02 0.037651333 1.00000000 2.3085269 0.9937311
#> 54: 0.1745250 2.851639e-01 0.170541531 1.00000000 0.8715085 0.9659046
#> 55: -0.1093000 6.787886e-02 -0.064977679 1.00000000 0.8690491 0.9637161
#> 56: -0.4685000 1.155108e-01 -0.292327907 1.00000000 5.0000000 0.9664211
#> 57: 0.0346250 6.120703e-02 0.079862131 1.00000000 1.0402312 0.9880428
#> 58: -0.4479500 4.605600e-02 -0.488835928 1.00000000 0.6769421 0.9907966
#> 59: -0.2010000 1.378341e-02 -0.159381313 1.00000000 1.7460087 0.9981365
#> 60: 0.3279750 5.323772e+00 -0.018947156 1.00000000 1.0587147 0.8873498
#> 61: 0.8758500 0.000000e+00 0.936377500 0.93637750 0.0001000 0.0000000
#> 62: -0.3945500 1.053934e-02 -0.399661994 1.00000000 1.1298982 0.9972903
#> 63: -0.0197250 1.366611e-01 0.060753470 1.00000000 1.0505188 0.9015657
#> 64: 0.0088000 8.766206e-02 0.040026446 0.94893204 1.2236015 0.9910767
#> 65: 0.1716000 3.888799e-02 0.173841652 0.99030733 0.7160123 0.9114592
#> 66: 0.1462250 2.814490e-02 0.160685311 1.04750604 1.4889745 0.9624206
#> 67: 0.1920750 1.080322e-01 0.336365670 0.98220588 5.0000000 0.8474508
#> 68: 0.5251875 2.045163e-01 0.507171357 1.04052978 0.6630559 0.7835605
#> 69: 0.1036500 8.708189e-03 0.119009772 1.10000000 0.7746648 0.8939315
#> 70: 0.6129625 7.447366e-02 0.658361037 1.07123428 1.5914510 0.9222046
#> x_max ec50 x_inf x_0 h r2
#> x_sd_avg fit_type maxlog10Concentration N_conc
#> 1: 0.052726289 DRC3pHillFitModelFixS0 1 10
#> 2: 0.072594530 DRC3pHillFitModelFixS0 1 10
#> 3: 0.066551346 DRC3pHillFitModelFixS0 1 10
#> 4: 0.079155838 DRC3pHillFitModelFixS0 1 10
#> 5: 0.064630529 DRC3pHillFitModelFixS0 1 10
#> 6: 0.055940590 DRC3pHillFitModelFixS0 1 10
#> 7: 0.041069121 DRC3pHillFitModelFixS0 1 10
#> 8: 0.094714176 DRC3pHillFitModelFixS0 1 10
#> 9: 0.064475771 DRC3pHillFitModelFixS0 1 10
#> 10: 0.044835058 DRC3pHillFitModelFixS0 1 10
#> 11: 0.105057654 DRC3pHillFitModelFixS0 1 10
#> 12: 0.125522607 DRCConstantFitResult 1 10
#> 13: 0.021448435 DRC3pHillFitModelFixS0 1 10
#> 14: 0.051042826 DRC3pHillFitModelFixS0 1 10
#> 15: 0.055701603 DRC4pHillFitModel 1 9
#> 16: 0.054001717 DRC3pHillFitModelFixS0 1 9
#> 17: 0.026771010 DRC4pHillFitModel 1 9
#> 18: 0.022131595 DRC3pHillFitModelFixS0 1 9
#> 19: 0.081250712 DRC4pHillFitModel 1 11
#> 20: 0.057529219 DRC4pHillFitModel 1 9
#> 21: 0.061758931 DRC3pHillFitModelFixS0 1 9
#> 22: 0.029497180 DRC3pHillFitModelFixS0 1 9
#> 23: 0.032293957 DRC4pHillFitModel 1 9
#> 24: 0.244786333 DRC4pHillFitModel 1 11
#> 25: 0.049373646 DRC4pHillFitModel 1 9
#> 26: 0.033951297 DRCConstantFitResult 1 9
#> 27: 0.017994393 DRC4pHillFitModel 1 9
#> 28: 0.011873562 DRCConstantFitResult 1 9
#> 29: 0.209893013 DRC4pHillFitModel 1 11
#> 30: 0.056758435 DRC4pHillFitModel 1 9
#> 31: 0.025307000 DRC4pHillFitModel 1 9
#> 32: 0.072188482 DRC3pHillFitModelFixS0 1 9
#> 33: 0.071859353 DRC3pHillFitModelFixS0 1 9
#> 34: 0.219450014 DRC4pHillFitModel 1 11
#> 35: 0.074121264 DRCConstantFitResult 1 9
#> 36: 0.084198329 DRCConstantFitResult 1 9
#> 37: 0.064807622 DRC3pHillFitModelFixS0 1 9
#> 38: 0.068421158 DRC3pHillFitModelFixS0 1 9
#> 39: 0.184016128 DRC4pHillFitModel 1 11
#> 40: 0.015505175 DRC3pHillFitModelFixS0 1 9
#> 41: 0.032642043 DRCConstantFitResult 1 9
#> 42: 0.004087448 DRCConstantFitResult 1 9
#> 43: 0.015330286 DRC4pHillFitModel 1 9
#> 44: 0.210560418 DRC4pHillFitModel 1 11
#> 45: 0.132721285 DRC4pHillFitModel 1 9
#> 46: 0.114442136 DRC3pHillFitModelFixS0 1 9
#> 47: 0.244999772 DRC4pHillFitModel 1 11
#> 48: 0.062224642 DRC4pHillFitModel 1 9
#> 49: 0.039540168 DRC3pHillFitModelFixS0 1 9
#> 50: 0.058877785 DRC3pHillFitModelFixS0 1 10
#> 51: 0.081977776 DRC3pHillFitModelFixS0 1 10
#> 52: 0.065819801 DRC3pHillFitModelFixS0 1 10
#> 53: 0.064284884 DRC3pHillFitModelFixS0 1 10
#> 54: 0.057494254 DRC3pHillFitModelFixS0 1 10
#> 55: 0.070762945 DRC3pHillFitModelFixS0 1 10
#> 56: 0.119999710 DRC3pHillFitModelFixS0 1 10
#> 57: 0.106228881 DRC3pHillFitModelFixS0 1 10
#> 58: 0.084499282 DRC3pHillFitModelFixS0 1 10
#> 59: 0.061471611 DRC3pHillFitModelFixS0 1 10
#> 60: 0.075383716 DRC3pHillFitModelFixS0 1 10
#> 61: 0.097688674 DRCConstantFitResult 1 10
#> 62: 0.032631452 DRC3pHillFitModelFixS0 1 10
#> 63: 0.181645413 DRC3pHillFitModelFixS0 1 10
#> 64: 0.097510798 DRC4pHillFitModel 1 11
#> 65: 0.159917137 DRC4pHillFitModel 1 11
#> 66: 0.160297842 DRC4pHillFitModel 1 11
#> 67: 0.224487916 DRC4pHillFitModel 1 11
#> 68: 0.170252556 DRC4pHillFitModel 1 11
#> 69: 0.121388378 DRC4pHillFitModel 1 11
#> 70: 0.077478277 DRC4pHillFitModel 1 11
#> x_sd_avg fit_type maxlog10Concentration N_conc
#> normalization_type fit_source cotrt_value source i.Gnumber
#> 1: RV gDR NA <NA> G02001876
#> 2: RV gDR NA <NA> G02001876
#> 3: RV gDR NA <NA> G02001876
#> 4: RV gDR NA <NA> G02001876
#> 5: RV gDR NA <NA> G02001876
#> 6: RV gDR NA <NA> G02001876
#> 7: RV gDR NA <NA> G02001876
#> 8: RV gDR NA <NA> G02967907
#> 9: RV gDR NA <NA> G02967907
#> 10: RV gDR NA <NA> G02967907
#> 11: RV gDR NA <NA> G02967907
#> 12: RV gDR NA <NA> G02967907
#> 13: RV gDR NA <NA> G02967907
#> 14: RV gDR NA <NA> G02967907
#> 15: GR gDR 0.1499999 row_fittings G02967907
#> 16: GR gDR 0.1000000 col_fittings G02967907
#> 17: RV gDR 0.1499999 row_fittings G02967907
#> 18: RV gDR 0.1000000 col_fittings G02967907
#> 19: RV gDR 0.0000000 row_fittings G02967907
#> 20: GR gDR 0.1499999 row_fittings G02967907
#> 21: GR gDR 0.1000000 col_fittings G02967907
#> 22: RV gDR 0.1000000 col_fittings G02967907
#> 23: RV gDR 0.1499999 row_fittings G02967907
#> 24: GR gDR 0.0000000 row_fittings G02967907
#> 25: GR gDR 0.1499999 row_fittings G02967907
#> 26: GR gDR 0.1000000 col_fittings G02967907
#> 27: RV gDR 0.1499999 row_fittings G02967907
#> 28: RV gDR 0.1000000 col_fittings G02967907
#> 29: GR gDR 0.0000000 row_fittings G02967907
#> 30: GR gDR 0.1499999 row_fittings G02967907
#> 31: RV gDR 0.1499999 row_fittings G02967907
#> 32: GR gDR 0.1000000 col_fittings G02967907
#> 33: RV gDR 0.1000000 col_fittings G02967907
#> 34: GR gDR 0.0000000 row_fittings G02967907
#> 35: RV gDR 0.1499999 row_fittings G02967907
#> 36: GR gDR 0.1499999 row_fittings G02967907
#> 37: RV gDR 0.1000000 col_fittings G02967907
#> 38: GR gDR 0.1000000 col_fittings G02967907
#> 39: RV gDR 0.0000000 row_fittings G02967907
#> 40: GR gDR 0.1000000 col_fittings G02967907
#> 41: GR gDR 0.1499999 row_fittings G02967907
#> 42: RV gDR 0.1000000 col_fittings G02967907
#> 43: RV gDR 0.1499999 row_fittings G02967907
#> 44: GR gDR 0.0000000 row_fittings G02967907
#> 45: GR gDR 0.1499999 row_fittings G02967907
#> 46: GR gDR 0.1000000 col_fittings G02967907
#> 47: GR gDR 0.0000000 row_fittings G02967907
#> 48: RV gDR 0.1499999 row_fittings G02967907
#> 49: RV gDR 0.1000000 col_fittings G02967907
#> 50: GR gDR NA <NA> G02001876
#> 51: GR gDR NA <NA> G02001876
#> 52: GR gDR NA <NA> G02001876
#> 53: GR gDR NA <NA> G02001876
#> 54: GR gDR NA <NA> G02001876
#> 55: GR gDR NA <NA> G02001876
#> 56: GR gDR NA <NA> G02001876
#> 57: GR gDR NA <NA> G02967907
#> 58: GR gDR NA <NA> G02967907
#> 59: GR gDR NA <NA> G02967907
#> 60: GR gDR NA <NA> G02967907
#> 61: GR gDR NA <NA> G02967907
#> 62: GR gDR NA <NA> G02967907
#> 63: GR gDR NA <NA> G02967907
#> 64: GR gDR 0.0000000 row_fittings G02967907
#> 65: RV gDR 0.0000000 row_fittings G02967907
#> 66: RV gDR 0.0000000 row_fittings G02967907
#> 67: RV gDR 0.0000000 row_fittings G02967907
#> 68: GR gDR 0.0000000 row_fittings G02967907
#> 69: RV gDR 0.0000000 row_fittings G02967907
#> 70: RV gDR 0.0000000 row_fittings G02967907
#> normalization_type fit_source cotrt_value source i.Gnumber
#> i.DrugName i.drug_moa i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3
#> 1: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 2: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 3: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 4: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 5: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 6: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 7: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 8: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 9: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 10: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 11: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 12: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 13: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 14: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 15: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 16: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 17: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 18: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 19: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 20: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 21: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 22: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 23: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 24: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 25: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 26: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 27: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 28: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 29: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 30: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 31: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 32: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 33: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 34: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 35: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 36: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 37: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 38: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 39: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 40: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 41: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 42: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 43: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 44: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 45: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 46: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 47: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 48: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 49: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 50: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 51: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 52: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 53: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 54: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 55: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 56: Palbociclib CDK4|CDK6 <NA> <NA> <NA> <NA>
#> 57: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 58: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 59: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 60: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 61: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 62: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 63: GDC-0077 PI3K-A <NA> <NA> <NA> <NA>
#> 64: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 65: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 66: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 67: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 68: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 69: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> 70: GDC-0077 PI3K-A G02001876 Palbociclib CDK4|CDK6 vehicle
#> i.DrugName i.drug_moa i.Gnumber_2 i.DrugName_2 i.drug_moa_2 i.DrugName_3
#> i.drug_moa_3 i.Duration i.clid i.CellLineName i.Tissue
#> 1: <NA> 168 CL129757 MCF-7 Breast
#> 2: <NA> 168 CL130218 BT-474 Breast
#> 3: <NA> 168 CL130742 T-47D Breast
#> 4: <NA> 168 CL131438 CAMA-1 Breast
#> 5: <NA> 168 CL131873 HCC1428 Breast
#> 6: <NA> 168 CL131891 EFM-19 Breast
#> 7: <NA> 168 CL131903 BT-483 Breast
#> 8: <NA> 168 CL129757 MCF-7 Breast
#> 9: <NA> 168 CL130218 BT-474 Breast
#> 10: <NA> 168 CL130742 T-47D Breast
#> 11: <NA> 168 CL131438 CAMA-1 Breast
#> 12: <NA> 168 CL131873 HCC1428 Breast
#> 13: <NA> 168 CL131891 EFM-19 Breast
#> 14: <NA> 168 CL131903 BT-483 Breast
#> 15: vehicle 168 CL129757 MCF-7 Breast
#> 16: vehicle 168 CL129757 MCF-7 Breast
#> 17: vehicle 168 CL129757 MCF-7 Breast
#> 18: vehicle 168 CL129757 MCF-7 Breast
#> 19: vehicle 168 CL129757 MCF-7 Breast
#> 20: vehicle 168 CL130218 BT-474 Breast
#> 21: vehicle 168 CL130218 BT-474 Breast
#> 22: vehicle 168 CL130218 BT-474 Breast
#> 23: vehicle 168 CL130218 BT-474 Breast
#> 24: vehicle 168 CL130218 BT-474 Breast
#> 25: vehicle 168 CL130742 T-47D Breast
#> 26: vehicle 168 CL130742 T-47D Breast
#> 27: vehicle 168 CL130742 T-47D Breast
#> 28: vehicle 168 CL130742 T-47D Breast
#> 29: vehicle 168 CL130742 T-47D Breast
#> 30: vehicle 168 CL131438 CAMA-1 Breast
#> 31: vehicle 168 CL131438 CAMA-1 Breast
#> 32: vehicle 168 CL131438 CAMA-1 Breast
#> 33: vehicle 168 CL131438 CAMA-1 Breast
#> 34: vehicle 168 CL131438 CAMA-1 Breast
#> 35: vehicle 168 CL131873 HCC1428 Breast
#> 36: vehicle 168 CL131873 HCC1428 Breast
#> 37: vehicle 168 CL131873 HCC1428 Breast
#> 38: vehicle 168 CL131873 HCC1428 Breast
#> 39: vehicle 168 CL131873 HCC1428 Breast
#> 40: vehicle 168 CL131891 EFM-19 Breast
#> 41: vehicle 168 CL131891 EFM-19 Breast
#> 42: vehicle 168 CL131891 EFM-19 Breast
#> 43: vehicle 168 CL131891 EFM-19 Breast
#> 44: vehicle 168 CL131891 EFM-19 Breast
#> 45: vehicle 168 CL131903 BT-483 Breast
#> 46: vehicle 168 CL131903 BT-483 Breast
#> 47: vehicle 168 CL131903 BT-483 Breast
#> 48: vehicle 168 CL131903 BT-483 Breast
#> 49: vehicle 168 CL131903 BT-483 Breast
#> 50: <NA> 168 CL129757 MCF-7 Breast
#> 51: <NA> 168 CL130218 BT-474 Breast
#> 52: <NA> 168 CL130742 T-47D Breast
#> 53: <NA> 168 CL131438 CAMA-1 Breast
#> 54: <NA> 168 CL131873 HCC1428 Breast
#> 55: <NA> 168 CL131891 EFM-19 Breast
#> 56: <NA> 168 CL131903 BT-483 Breast
#> 57: <NA> 168 CL129757 MCF-7 Breast
#> 58: <NA> 168 CL130218 BT-474 Breast
#> 59: <NA> 168 CL130742 T-47D Breast
#> 60: <NA> 168 CL131438 CAMA-1 Breast
#> 61: <NA> 168 CL131873 HCC1428 Breast
#> 62: <NA> 168 CL131891 EFM-19 Breast
#> 63: <NA> 168 CL131903 BT-483 Breast
#> 64: vehicle 168 CL129757 MCF-7 Breast
#> 65: vehicle 168 CL130218 BT-474 Breast
#> 66: vehicle 168 CL130742 T-47D Breast
#> 67: vehicle 168 CL131438 CAMA-1 Breast
#> 68: vehicle 168 CL131873 HCC1428 Breast
#> 69: vehicle 168 CL131891 EFM-19 Breast
#> 70: vehicle 168 CL131903 BT-483 Breast
#> i.drug_moa_3 i.Duration i.clid i.CellLineName i.Tissue
#> i.parental_identifier i.subtype i.ReferenceDivisionTime
#> 1: MCF-7 unknown 30
#> 2: BT-474 unknown 70
#> 3: T-47D unknown 60
#> 4: CAMA-1 unknown 53
#> 5: HCC1428 unknown 74
#> 6: EFM-19 unknown 64
#> 7: BT-483 unknown 130
#> 8: MCF-7 unknown 30
#> 9: BT-474 unknown 70
#> 10: T-47D unknown 60
#> 11: CAMA-1 unknown 53
#> 12: HCC1428 unknown 74
#> 13: EFM-19 unknown 64
#> 14: BT-483 unknown 130
#> 15: MCF-7 unknown 30
#> 16: MCF-7 unknown 30
#> 17: MCF-7 unknown 30
#> 18: MCF-7 unknown 30
#> 19: MCF-7 unknown 30
#> 20: BT-474 unknown 70
#> 21: BT-474 unknown 70
#> 22: BT-474 unknown 70
#> 23: BT-474 unknown 70
#> 24: BT-474 unknown 70
#> 25: T-47D unknown 60
#> 26: T-47D unknown 60
#> 27: T-47D unknown 60
#> 28: T-47D unknown 60
#> 29: T-47D unknown 60
#> 30: CAMA-1 unknown 53
#> 31: CAMA-1 unknown 53
#> 32: CAMA-1 unknown 53
#> 33: CAMA-1 unknown 53
#> 34: CAMA-1 unknown 53
#> 35: HCC1428 unknown 74
#> 36: HCC1428 unknown 74
#> 37: HCC1428 unknown 74
#> 38: HCC1428 unknown 74
#> 39: HCC1428 unknown 74
#> 40: EFM-19 unknown 64
#> 41: EFM-19 unknown 64
#> 42: EFM-19 unknown 64
#> 43: EFM-19 unknown 64
#> 44: EFM-19 unknown 64
#> 45: BT-483 unknown 130
#> 46: BT-483 unknown 130
#> 47: BT-483 unknown 130
#> 48: BT-483 unknown 130
#> 49: BT-483 unknown 130
#> 50: MCF-7 unknown 30
#> 51: BT-474 unknown 70
#> 52: T-47D unknown 60
#> 53: CAMA-1 unknown 53
#> 54: HCC1428 unknown 74
#> 55: EFM-19 unknown 64
#> 56: BT-483 unknown 130
#> 57: MCF-7 unknown 30
#> 58: BT-474 unknown 70
#> 59: T-47D unknown 60
#> 60: CAMA-1 unknown 53
#> 61: HCC1428 unknown 74
#> 62: EFM-19 unknown 64
#> 63: BT-483 unknown 130
#> 64: MCF-7 unknown 30
#> 65: BT-474 unknown 70
#> 66: T-47D unknown 60
#> 67: CAMA-1 unknown 53
#> 68: HCC1428 unknown 74
#> 69: EFM-19 unknown 64
#> 70: BT-483 unknown 130
#> i.parental_identifier i.subtype i.ReferenceDivisionTimeassayNames(tre)
#> [1] "RawTreated" "Controls" "Normalized" "Averaged"
#> [5] "SmoothMatrix" "BlissExcess" "HSAExcess" "all_iso_points"
#> [9] "isobolograms" "BlissScore" "HSAScore" "CIScore_50"
#> [13] "CIScore_80" "Metrics"head(assay(tre, "Metrics"),3)
#> treatmentid sampleid
#> 1: G02001876_Palbociclib_CDK4|CDK6_168 CL129757_MCF-7_Breast_MCF-7_unknown_30
#> 2: G02001876_Palbociclib_CDK4|CDK6_168 CL130218_BT-474_Breast_BT-474_unknown_70
#> 3: G02001876_Palbociclib_CDK4|CDK6_168 CL130742_T-47D_Breast_T-47D_unknown_60
#> DrugName DrugName_2 DrugName_3 Duration Gnumber Gnumber_2 drug_moa
#> 1: Palbociclib <NA> <NA> 168 G02001876 <NA> CDK4|CDK6
#> 2: Palbociclib <NA> <NA> 168 G02001876 <NA> CDK4|CDK6
#> 3: Palbociclib <NA> <NA> 168 G02001876 <NA> CDK4|CDK6
#> drug_moa_2 drug_moa_3 CellLineName ReferenceDivisionTime Tissue clid
#> 1: <NA> <NA> MCF-7 30 Breast CL129757
#> 2: <NA> <NA> BT-474 70 Breast CL130218
#> 3: <NA> <NA> T-47D 60 Breast CL130742
#> parental_identifier subtype data_type x_mean x_AOC x_AOC_range
#> 1: MCF-7 unknown single-agent 0.4774514 0.5225486 0.5592516
#> 2: BT-474 unknown single-agent 0.5916887 0.4083113 0.4338082
#> 3: T-47D unknown single-agent 0.5478704 0.4521296 0.4876840
#> xc50 x_max ec50 x_inf x_0 h r2 x_sd_avg
#> 1: 0.1100133 -0.017025 0.1161741 -0.03117468 1 1.1100114 0.9880388 0.05887778
#> 2: 0.2091202 0.114275 0.1360264 0.16571556 1 0.9361851 0.9555750 0.08197778
#> 3: 0.1164343 0.111425 0.1033672 0.13053185 1 2.5415386 0.9815621 0.06581980
#> fit_type maxlog10Concentration N_conc normalization_type
#> 1: DRC3pHillFitModelFixS0 1 10 GR
#> 2: DRC3pHillFitModelFixS0 1 10 GR
#> 3: DRC3pHillFitModelFixS0 1 10 GR
#> fit_source cotrt_value source i.Gnumber i.DrugName i.drug_moa i.Gnumber_2
#> 1: gDR NA <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 2: gDR NA <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> 3: gDR NA <NA> G02001876 Palbociclib CDK4|CDK6 <NA>
#> i.DrugName_2 i.drug_moa_2 i.DrugName_3 i.drug_moa_3 i.Duration i.clid
#> 1: <NA> <NA> <NA> <NA> 168 CL129757
#> 2: <NA> <NA> <NA> <NA> 168 CL130218
#> 3: <NA> <NA> <NA> <NA> 168 CL130742
#> i.CellLineName i.Tissue i.parental_identifier i.subtype
#> 1: MCF-7 Breast MCF-7 unknown
#> 2: BT-474 Breast BT-474 unknown
#> 3: T-47D Breast T-47D unknown
#> i.ReferenceDivisionTime
#> 1: 30
#> 2: 70
#> 3: 60sessionInfo()
#> R version 4.3.1 (2023-06-16)
#> Platform: x86_64-pc-linux-gnu (64-bit)
#> Running under: Ubuntu 22.04.3 LTS
#>
#> Matrix products: default
#> BLAS: /home/biocbuild/bbs-3.18-bioc/R/lib/libRblas.so
#> LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.10.0
#>
#> locale:
#> [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
#> [3] LC_TIME=en_GB LC_COLLATE=C
#> [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
#> [7] LC_PAPER=en_US.UTF-8 LC_NAME=C
#> [9] LC_ADDRESS=C LC_TELEPHONE=C
#> [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
#>
#> time zone: America/New_York
#> tzcode source: system (glibc)
#>
#> attached base packages:
#> [1] stats4 stats graphics grDevices utils datasets methods
#> [8] base
#>
#> other attached packages:
#> [1] MultiAssayExperiment_1.28.0 gDRimport_1.0.0
#> [3] PharmacoGx_3.6.0 CoreGx_2.6.0
#> [5] SummarizedExperiment_1.32.0 Biobase_2.62.0
#> [7] GenomicRanges_1.54.0 GenomeInfoDb_1.38.0
#> [9] IRanges_2.36.0 S4Vectors_0.40.0
#> [11] MatrixGenerics_1.14.0 matrixStats_1.0.0
#> [13] BiocGenerics_0.48.0
#>
#> loaded via a namespace (and not attached):
#> [1] bitops_1.0-7 rlang_1.1.1 magrittr_2.0.3
#> [4] shinydashboard_0.7.2 compiler_4.3.1 reshape2_1.4.4
#> [7] maps_3.4.1 vctrs_0.6.4 relations_0.6-13
#> [10] stringr_1.5.0 pkgconfig_2.0.3 crayon_1.5.2
#> [13] fastmap_1.1.1 backports_1.4.1 XVector_0.42.0
#> [16] ellipsis_0.3.2 caTools_1.18.2 utf8_1.2.4
#> [19] promises_1.2.1 rmarkdown_2.25 pracma_2.4.2
#> [22] magicaxis_2.2.14 coop_0.6-3 xfun_0.40
#> [25] zlibbioc_1.48.0 cachem_1.0.8 celestial_1.4.6
#> [28] jsonlite_1.8.7 SnowballC_0.7.1 later_1.3.1
#> [31] DelayedArray_0.28.0 BiocParallel_1.36.0 parallel_4.3.1
#> [34] sets_1.0-24 cluster_2.1.4 R6_2.5.1
#> [37] stringi_1.7.12 bslib_0.5.1 RColorBrewer_1.1-3
#> [40] qs_0.25.5 limma_3.58.0 boot_1.3-28.1
#> [43] jquerylib_0.1.4 Rcpp_1.0.11 knitr_1.44
#> [46] downloader_0.4 httpuv_1.6.12 Matrix_1.6-1.1
#> [49] igraph_1.5.1 tidyselect_1.2.0 abind_1.4-5
#> [52] yaml_2.3.7 stringfish_0.15.8 gplots_3.1.3
#> [55] codetools_0.2-19 plyr_1.8.9 lattice_0.22-5
#> [58] tibble_3.2.1 shiny_1.7.5.1 BumpyMatrix_1.10.0
#> [61] evaluate_0.22 RcppParallel_5.1.7 bench_1.1.3
#> [64] pillar_1.9.0 lsa_0.73.3 KernSmooth_2.23-22
#> [67] sm_2.2-5.7.1 checkmate_2.2.0 DT_0.30
#> [70] shinyjs_2.1.0 piano_2.18.0 generics_0.1.3
#> [73] RCurl_1.98-1.12 ggplot2_3.4.4 munsell_0.5.0
#> [76] scales_1.2.1 RApiSerialize_0.1.2 gtools_3.9.4
#> [79] xtable_1.8-4 marray_1.80.0 glue_1.6.2
#> [82] slam_0.1-50 mapproj_1.2.11 tools_4.3.1
#> [85] data.table_1.14.8 gDRutils_1.0.0 fgsea_1.28.0
#> [88] RANN_2.6.1 visNetwork_2.1.2 fastmatch_1.1-4
#> [91] cowplot_1.1.1 grid_4.3.1 plotrix_3.8-2
#> [94] NISTunits_1.0.1 colorspace_2.1-0 GenomeInfoDbData_1.2.11
#> [97] cli_3.6.1 fansi_1.0.5 S4Arrays_1.2.0
#> [100] dplyr_1.1.3 gtable_0.3.4 sass_0.4.7
#> [103] digest_0.6.33 SparseArray_1.2.0 htmlwidgets_1.6.2
#> [106] htmltools_0.5.6.1 lifecycle_1.0.3 statmod_1.5.0
#> [109] mime_0.12 MASS_7.3-60