motifbreakR
A Package For Predicting The Disruptiveness Of Single Nucleotide Polymorphisms On Transcription Factor Binding Sites
Bioconductor version: Release (3.19)
We introduce motifbreakR, which allows the biologist to judge in the first place whether the sequence surrounding the polymorphism is a good match, and in the second place how much information is gained or lost in one allele of the polymorphism relative to another. MotifbreakR is both flexible and extensible over previous offerings; giving a choice of algorithms for interrogation of genomes with motifs from public sources that users can choose from; these are 1) a weighted-sum probability matrix, 2) log-probabilities, and 3) weighted by relative entropy. MotifbreakR can predict effects for novel or previously described variants in public databases, making it suitable for tasks beyond the scope of its original design. Lastly, it can be used to interrogate any genome curated within Bioconductor (currently there are 32 species, a total of 109 versions).
Author: Simon Gert Coetzee [aut, cre], Dennis J. Hazelett [aut]
Maintainer: Simon Gert Coetzee <simon.coetzee at cshs.org>
citation("motifbreakR")):
Installation
To install this package, start R (version "4.4") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("motifbreakR")
For older versions of R, please refer to the appropriate Bioconductor release.
Documentation
To view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("motifbreakR")| motifbreakR: an Introduction | HTML | R Script |
| Reference Manual |
Details
| biocViews | ChIPSeq, MotifAnnotation, Software, Transcription, Visualization |
| Version | 2.18.0 |
| In Bioconductor since | BioC 3.2 (R-3.2) (9 years) |
| License | GPL-2 |
| Depends | R (>= 4.3.0), grid, MotifDb |
| Imports | methods, grDevices, stringr, parallel, BiocGenerics, S4Vectors(>= 0.9.25), IRanges, GenomeInfoDb, GenomicRanges, Biostrings, BSgenome, rtracklayer, VariantAnnotation, BiocParallel, motifStack, Gviz, matrixStats, TFMPvalue, SummarizedExperiment, pwalign |
| System Requirements | |
| URL | |
| Bug Reports | https://github.com/Simon-Coetzee/motifbreakR/issues |
See More
| Suggests | BSgenome.Hsapiens.UCSC.hg19, SNPlocs.Hsapiens.dbSNP155.GRCh37, knitr, rmarkdown, BSgenome.Drerio.UCSC.danRer7, BiocStyle |
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| Depends On Me | |
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| Build Report | Build Report |
Package Archives
Follow Installation instructions to use this package in your R session.
| Source Package | motifbreakR_2.18.0.tar.gz |
| Windows Binary (x86_64) | motifbreakR_2.18.0.zip |
| macOS Binary (x86_64) | motifbreakR_2.18.0.tgz |
| macOS Binary (arm64) | motifbreakR_2.18.0.tgz |
| Source Repository | git clone https://git.bioconductor.org/packages/motifbreakR |
| Source Repository (Developer Access) | git clone [email protected]:packages/motifbreakR |
| Bioc Package Browser | https://code.bioconductor.org/browse/motifbreakR/ |
| Package Short Url | https://bioconductor.org/packages/motifbreakR/ |
| Package Downloads Report | Download Stats |